兔抗CD136抗体 | MyBioSource MBS462021 产品信息

产品简要

公司名称 :

MyBioSource

产品类型 :

抗体

产品名称 :

兔抗CD136抗体

MBS462021

规格 :

0.1毫克

价格 :

265美元

克隆性 :

多克隆

宿主 :

兔

共轭标签 :

未共轭

反应物种 :

人类, 小鼠

应用 :

免疫印迹, 酶联免疫吸附测定, 免疫组化

更多信息或购买 :

MyBioSource 产品网页

产品信息

目录号 :

MBS462021

产品类型 :

抗体

产品全称 :

兔抗CD136抗体

产品简称 :

CD136(RON)

产品名称同义词 :

Rabbit anti-CD136; Recepteur d’origine nantais (RON); Macrophage-Stimulating 1 Receptor (MST1R).

产品基因名称 :

CD136(RON)

克隆性 :

多克隆

宿主 :

兔

反应物种 :

人类, 大鼠, 小鼠

特异性 :

This antibody recognizes ~175 kDa of human LRP5 protein. It also reacts with mouse and rat. The other species are not tested.

纯度 :

The Rabbit IgG is purified by Site-specific Epitope Affinity Purification.

形式 :

This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer

浓度 :

Size: 100 ug/200 ul

储存稳定性 :

The antibodies are stable for 12 months from date of receipt when stored at -20 degree C to -70 degree C. The antibodies can be stored at 2 degree C-8 degree C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycle

检测过的应用 :

酶联免疫吸附测定, 免疫印迹, 免疫组化

应用笔记 :

Western Blot: 0.1-1 ug/ml. ELISA: 0.01-0.1 ug/ml. Immunoprecipitation: 2-5 ug/ml. Immunohistochemistry: 2-5 ug/ml

其它信息1 :

Antigen Preparation: A synthetic peptide corresponding to the human CD136 at internal domain. This sequence is identical to mouse or rat origin.

其他信息2 :

Positive Control: CD136 transfected HEK293

产品描述 :

CD136, a transmembrane receptor tyrosine kinase, also known as Macrophage stimulating 1 receptor (MST1R) and RON (Recepteur d'origine nantais), is a member of the MET proto-oncogene family (63% homology), and is the receptor for macrophage-stimulating protein (MSP), a multifunctional cytokine that regulates cell adhesion, motility, growth, and survival. Binding of MSP to CD136 stimulates tyrosine phosphorylation on Tyr 1238 and Tyr 1239. This phosphorylation leads to a upregulation of CD136 catalytic activity and subsequent activation of downstream signaling molecules. In addition, CD136 contains putative autophosphorylation sites on Tyr 1353 and Tyr 1360. RON mediates multiple signaling cascades, such as MAPK, PI3K/AKT, FAK pathways. CD136 activation can also significantly increase C-Src activity. CD136 is a disulfide-linked 180kD heterodimer composed of a 35kD alpha chain and a 150kD beta chain, and is mainly expressed in cells of epithelial origin. CD136 is thought to play a role in early embryonic development and in the inflammatory response as well as implicated in the progression and metastasis of tumors including those of the breast and colon.

NCBI分子量 :

185 kDa

尺寸1 :

0.1毫克

价格1 :

265美元

更多信息或购买 :

MyBioSource 产品网页

公司信息