抗体

兔抗基质金属蛋白酶-2多克隆抗体

MBS462081

0.1毫克

350美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠, 狗, 鸡

免疫印迹, 酶联免疫吸附测定, 免疫组化

抗体

兔抗基质金属蛋白酶-2多克隆抗体

基质金属蛋白酶-2

Rabbit anti-MMP-2; Matrix Metalloproteinase 2 (MMP2); Gelatinase A; 72 kDa type IV collagenase precursor

MMP-2; MMP-2; 72 kDa type IV collagenase; MMP-2; gelatinase A; 72 kDa gelatinase; matrix metalloproteinase 2; matrix metalloproteinase-2; matrix metallopeptidase 2

基质金属蛋白酶-2

Mmp2;Mmp2;基质金属蛋白酶-2

Q9JHC2_RAT

多克隆

兔

人类, 大鼠, 小鼠, 鸡, 狗

This antibody recognizes ~62 and 72 kDa of human MMP2 protein. This antibody reacts with human, rat, mouse. The other species are not tested.

The Rabbit IgG is purified by Epitope Affinity Purification.

This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer

Size: 100 ug/200 ul

The antibodies are stable for 12 months from date of receipt when stored at -20 degree C to -70 degree C. The antibodies can be stored at 2 degree C -8 degree C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.

酶联免疫吸附测定, 免疫印迹, 免疫组化

Western Blot: 0.1-1 ug/ml. ELISA: 0.01-0.1 ug/ml. Immunoprecipitation: 2-5 ug/ml. Immunohistochemistry: 2-5 ug/ml

Antigen Preparation: A synthetic peptide corresponding to C-term of human MMP2. This sequence is identical among human, rat, mouse, chicken, dog and bovine.

Positive Control: Breast cancer. Cellular Location: Cytoplasmic and extracellular matrix

Matrix metalloproteinases (MMPs) belong to a family of proteinases that target many extracellular matrix proteins including additional proteinases, growth factors, cell surface receptors and adhesion molecules. MMPs contain common domain structures that include a signal sequence, a propeptide, a catalytic domain, and a hemopexin-like (Hpx) domain. The MMP activity requires proteolytic cleavage of MMPs in order to generate activie MMPs by release of the inhibitory propeptide domain from the whole molecules. MMP-2, MMP-3, MMP-7, MMP-9 and MMP-13 have been characterized as important factors for normal tissue remodeling during embryo development and wound healing, tumor invasion, angiogenesis, carcinogenesis and apoptosis. MMP activities are correlated with cancer metastatic process.

Brigitte Lelongt, et al. Matrix Metalloproteinases MMP2 and MMP9 Are Produced in Early Stages of Kidney Morphogenesis but Only MMP9 Is Required for Renal Organogenesis In Vitro. J. Cell Biol. 1997. 136 (6), 1363-1373.

8050250

Q9JHC2

62kDa, 72 kDa

Bladder Cancer Pathway (83503); Bladder Cancer Pathway (527); GnRH Signaling Pathway (83483); GnRH Signaling Pathway (502); IL-3 Signaling Pathway (198504); Leukocyte Transendothelial Migration Pathway (83475); Leukocyte Transendothelial Migration Pathway (494); Matrix Metalloproteinases Pathway (198492); Pathways In Cancer (83493)

plays important roles in wound healing, angiogenesis, platelet aggregation, and tumor metastasis; mediates the response of the intrinsic glomerular mesangial cell to inflammatory stimuli [RGD]

0.1毫克

350美元