产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
兔抗基质金属蛋白酶-7多克隆抗体
目录 :
MBS462082
规格 :
0.1毫克
价格 :
350美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化
更多信息或购买 :
产品信息
目录号 :
MBS462082
产品类型 :
抗体
产品全称 :
兔抗基质金属蛋白酶-7多克隆抗体
产品简称 :
基质金属蛋白酶-7(基质溶解素)
产品名称同义词 :
兔抗基质金属蛋白酶-7;基质金属蛋白酶7(基质金属蛋白酶-7);基质溶解素;PUMP-1
其他名称 :
matrilysin preproprotein; Matrilysin; matrilysin; matrin; pump-1 protease; OTTHUMP00000045867; uterine matrilysin; uterine metalloproteinase; matrix metalloproteinase-7; matrix metalloproteinase 7 (matrilysin, uterine); matrix metallopeptidase 7 (matrilysin, uterine); Matrin; Matrix metalloproteinase-7; MMP-7; Pump-1 protease; Uterine metalloproteinase
产品基因名称 :
基质金属蛋白酶-7(基质溶解素)
其他基因名称 :
MMP7;MMP7;基质金属蛋白酶-7;MPSL1;PUMP-1;MPSL1;PUMP1
UniProt数据库进入名 :
MMP7_HUMAN
克隆性 :
多克隆
宿主 :
反应物种 :
人类
特异性 :
This antibody recognizes ~30 kDa of human MMP-7 protein. The other species are not tested.
纯度 :
The Rabbit IgG is purified by Epitope Affinity Purification.
形式 :
This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer
浓度 :
Size: 100 ug/200 ul
储存稳定性 :
The antibodies are stable for 12 months from date of receipt when stored at -20 degree C to -70 degree C. The antibodies can be stored at 2 degree C -8 degree C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
检测过的应用 :
酶联免疫吸附测定, 免疫印迹, 免疫组化
应用笔记 :
Western Blot: 0.1-1 ug/ml. ELISA: 0.01-0.1 ug/ml. Immunoprecipitation: 2-5 ug/ml. Immunohistochemistry: 2-5 ug/ml
其它信息1 :
Antigen Preparation: A synthetic peptide corresponding to the C-terminus of human MMP-7. This sequence is identical among bovine and monkey.
其他信息2 :
Positive Control: Conditioned A431. Cellular Location: Cytoplasmic and extracellular matrix
产品描述 :
Matrix metalloproteinases (MMPs) belong to a family of proteinases that target many extracellular matrix proteins including additional proteinases, growth factors, cell surface receptors and adhesion molecules. MMPs contain common domain structures that include a signal sequence, a propeptide, a catalytic domain, and a hemopexin-like (Hpx) domain. The MMP activity requires proteolytic cleavage of MMPs in order to generate activie MMPs by release of the inhibitory propeptide domain from the whole molecules. MMP-2, MMP-3, MMP-7, MMP-9 and MMP-13 have been characterized as important factors for normal tissue remodeling during embryo development and wound healing, tumor invasion, angiogenesis, carcinogenesis and apoptosis. MMP activities are correlated with cancer metastatic process. MMP-7, also known as matrilysin/PUMP-1, plays an important role in hydrolyzing proteoglycans and ECM glycoproteins. It is also expressed in normal cells, specifically glandular epithelial cells. In pancreatic carcinoma, the higher expression of MMP-2, 7 and 11 is observed.
产品引用 :
Nick Di Girolamo, et al. Active Matrilysin (MMP-7) in Human Pterygia: Potential Role in Angiogenesis. Investigative Ophthalmology and Visual Science. 2001;42:1963-1968.
NCBI GI登录号 :
4505219
NCBI登录号 :
NP_002414.1
NCBI基因登录号 :
NM_002423.3
UniProt数据库登录号 :
P09237
NCBI分子量 :
30 kDa, (18 kDa)
NCBI信号通路 :
Alpha6-Beta4 Integrin Signaling Pathway (198807); Matrix Metalloproteinases Pathway (198900); Syndecan-1-mediated Signaling Events Pathway (138046); Wnt Signaling Pathway And Pluripotency (198847); Wnt Signaling Pathway (83061); Wnt Signaling Pathway (471); P75(NTR)-mediated Signaling Pathway (138019)
NCBI总结 :
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq]
UniProt数据库总结 :
Function: Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase. Ref.7. Catalytic activity: Cleavage of 14-Ala- -Leu-15 and 16-Tyr- -Leu-17 in B chain of insulin. No action on collagen types I, II, IV, V. Cleaves gelatin chain alpha-2(I) > alpha-1(I). Cofactor: Binds 2 calcium ions per subunit.Binds 2 zinc ions per subunit. Subcellular location: Secreted extracellular space extracellular matrix. Probable. Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme. Sequence similarities: Belongs to the peptidase M10A family.
尺寸1 :
0.1毫克
价格1 :
350美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。