兔抗哺乳动物雷帕霉素靶蛋白多克隆抗体 | MyBioSource MBS462086 产品信息

产品简要

公司名称 :

MyBioSource

产品类型 :

抗体

产品名称 :

兔抗哺乳动物雷帕霉素靶蛋白多克隆抗体

MBS462086

规格 :

0.1毫克

价格 :

250美元

克隆性 :

多克隆

宿主 :

兔

共轭标签 :

未共轭

反应物种 :

人类, 小鼠, 狗, 鸡

应用 :

免疫印迹, 酶联免疫吸附测定, 免疫组化

更多信息或购买 :

MyBioSource 产品网页

产品信息

目录号 :

MBS462086

产品类型 :

抗体

产品全称 :

兔抗哺乳动物雷帕霉素靶蛋白多克隆抗体

产品简称 :

哺乳动物雷帕霉素靶蛋白

产品名称同义词 :

Rabbit anti-mTOR; Mammalian target of rapamycin (mTOR); RAPT1; FKBP12-Rapamycin;

产品基因名称 :

哺乳动物雷帕霉素靶蛋白

克隆性 :

多克隆

宿主 :

兔

反应物种 :

人类, 大鼠, 小鼠, 牛, 狗, 鸡

特异性 :

This antibody only recognizes ~290 kDa of human mTOR. It also reacts with mouse and rat mTOR protein. The other species are not tested.

纯度 :

The Rabbit IgG is purified by Epitope Affinity Purification.

形式 :

This affinity purified antibody is supplied in sterile phosphatebuffered saline (pH7.2) containing antibody stabilizer

浓度 :

Size: 100 ug/200 ul

储存稳定性 :

The antibodies are stable for 12 months from date of receipt when stored at -20 degree C to -70 degree C. The antibodies can be stored at 2 degree C -8 degree C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.

检测过的应用 :

酶联免疫吸附测定, 免疫印迹, 免疫组化

应用笔记 :

Western Blot: 0.1-1 ug/ml. ELISA: 0.01-0.1 ug/ml. Immunoprecipitation: 2-5 ug/ml

其它信息1 :

Antigen Preparation: A synthetic peptide corresponding to the C-terminus of human mTOR protein. This sequence is identical among human, rat, mouse, chicken, dog and bovine species.

其他信息2 :

Positive Control: MCF-7

产品描述 :

The mammalian target of rapamycin (mTOR), also named FKBP12 rapamycin-associated protein (FRAP/RAFT/RAPT/SEP), is a Ser/Thr protein kinase that plays a crucial role in a nutrient-sensitive signalling pathway that regulates cell growth. TOR signalling is potently inhibited by rapamycin, through the direct binding of a FK506-binding protein 12 (FKBP12)/rapamycin complex to the TOR FRB domain, a segment amino terminal to the kinase catalytic domain. mTOR is involved in the regulation of cell growth through initiation of gene translation in response to nutrients such as amino acids (mainly leucine), growth factors, insulin and mitogens. mTOR initiates translation by activating the ribosomal p70S6k protein kinase (S6K1) and by inhibiting the eIF4E inhibitor 4E-BP1. mTOR is phosphorylated at serine 2448 via the phosphatidylinositol 3-kinase (PI3K)/Akt pathway and is autophosphorylated at serine 2481.

产品引用 :

Noriko Oshiro, et al. Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function (2004), Genes to Cells (2004) 9, 359-366.

NCBI分子量 :

290 kDa

尺寸1 :

0.1毫克

价格1 :

250美元

更多信息或购买 :

MyBioSource 产品网页

公司信息