抗体

小鼠抗CXCR3单克隆抗体

MBS462161

0.1毫克

305美元

单克隆

小鼠

未共轭

1C6

酶联免疫吸附测定, 免疫组化, 流式细胞仪

抗体

小鼠抗CXCR3单克隆抗体

CXCR3

Mouse anti-CXCR3; Chemokine CXC Motif receptor 3; CD183; GPR9; IP10R; MIGR

C-X-C chemokine receptor type 3 isoform 2; C-X-C chemokine receptor type 3; C-X-C chemokine receptor type 3; CXC-R3; CXCR-3; Mig receptor; IP10 receptor; IP-10 receptor; OTTHUMP00000032170; OTTHUMP00000070257; G protein-coupled receptor 9; chemokine (C-X-C) receptor 3; interferon-inducible protein 10 receptor; chemokine (C-X-C motif) receptor 3; CKR-L2; G protein-coupled receptor 9; Interferon-inducible protein 10 receptor

CXCR3

CXCR3; CXCR3; GPR9; MigR; CD182; CD183; Mig-R; CKR-L2; CMKAR3; IP10-R; GPR9

CXCR3_HUMAN

单克隆

IgG1, k

1C6

小鼠

人类

This antibody recognizes surface expressed CXCR3, and/or PHA or anti-CD3 activated human T cells. The other species are not tested.

The mouse IgG1 is purified by Protein A-Affinity Chromatography according to Isotyping

This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer

Size: 100 ug/200 ul

The antibodies are stable for 12 months from date of receipt when stored at -20 degree C to -70 degree C. The antibodies can be stored at 2 degree C-8 degree C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.

酶联免疫吸附测定, 流式细胞仪, 免疫组化

Western Blot: 0.5-2 ug/ml. ELISA: 0.1-1 ug/ml. Immunoprecipitation: 2-5 ug/ml. Immunohistochemistry: 1:500. Flow Cytometry: 2-5 ug/ml

Antigen Preparation: A 37aa-synthetic peptide corresponding to the N-terminus of human CXCR3 conjugated to KLH.

Positive Control: Transfected CXCR3 Cells. Cellular Location: Cell Membrane

Chemokine receptors are seven-transmembrane domain G-protein coupled receptors that mediate the biological activities of chemokines. Most of these receptors exhibit promiscuous binding properties whereby several different chemokines signal through the same receptor. They are named according to the chemokine subfamily they bind. There are currently six CXCspecific receptors designated CXCR1 to CXCR6. This antibody recognizes surface expressed CXCR3, as judged by staining of CXCR3 transfected cells, but not untransfected cells. The antibody also stained human T cells and T cell clones that had been activated in vitro with PHA or anti-CD3. However, the anti-CXCR3 antibody did not react with neutrophils. The CXCR3 receptor is also known as the IP-10 receptor and the Mig receptor.

Qin S, et al. The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions. J. Clin. Invest. 101: 746-754, 1998.

218563730

NP_001136269.1

NM_001142797.1

P49682

~41 kDa

CXCR3-mediated Signaling Events Pathway (138011); Chemokine Receptors Bind Chemokines Pathway (106359); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); G Alpha (i) Signalling Events Pathway (119550); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020)

This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq]

Function: Receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HMC). Ref.2 Ref.8Isoform 2 is a receptor for CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the growth of human microvascular endothelial cells (HMVEC). May play a role in angiogenesis. Ref.2 Ref.8Isoform 3 mediates the activity of CXCL11. Ref.2 Ref.8. Subcellular location: Cell membrane; Multi-pass membrane protein. Tissue specificity: Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta. Ref.2. Sequence similarities: Belongs to the G-protein coupled receptor 1 family. Sequence caution: The sequence CAB02143.1 differs from that shown. Reason: Erroneous initiation.

0.1毫克

305美元