Cdc42 | MyBioSource MBS470007 产品信息

产品简要

公司名称 :

MyBioSource

产品类型 :

抗体

产品名称 :

Cdc42

MBS470007

规格 :

0.1毫升

价格 :

280美元

克隆性 :

单克隆

宿主 :

小鼠

共轭标签 :

未共轭

反应物种 :

人类

应用 :

免疫印迹, 酶联免疫吸附测定, 免疫细胞化学

更多信息或购买 :

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产品信息

目录号 :

MBS470007

产品类型 :

抗体

产品全称 :

Cdc42

产品简称 :

Cdc42

产品名称同义词 :

细胞分裂周期42;GTP结合蛋白25-KD;G25K

其他名称 :

cell division cycle 42 (GTP binding protein, 25kDa); Cell division cycle 42 (GTP binding protein, 25kDa); cell division control protein 42 homolog; OTTHUMP00000002834; OTTHUMP00000002926; G25K GTP-binding protein; GTP-binding protein, 25kD; growth-regulating protein; small GTP binding protein CDC42; dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD)); dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD)); cell division cycle 42 (GTP binding protein, 25kDa)

其他基因名称 :

CDC42;CDC42;G25K;CDC42Hs

UniProt数据库进入名 :

Q5JYX0_HUMAN

克隆性 :

单克隆

抗体亚型 :

IgG1

宿主 :

小鼠

反应物种 :

人类, 大鼠, 小鼠

序列长度 :

136

特异性 :

The antibody detects a 21 kDa* protein in human Jurkat cells and mouse brain. It does not recognize a human RhoA GST fusion protein.

纯度 :

蛋白质A纯化

形式 :

Mouse monoclonal antibody purified with protein A chromatography is supplied in 100ml phosphate-buffered saline, 50% glycerol, 1 mg/ml BSA, and 0.05% sodium azide.

储存稳定性 :

Store at -20 degree C. Do not aliquot. Stable for 1 year.

检测过的应用 :

酶联免疫吸附测定, 免疫印迹, 免疫细胞化学

应用笔记 :

ELISA: 1:2000. Immunocytochemistry: 1:50. Western Blot: 1:500

其它信息1 :

Immunogen: Clone (M152) was generated from a rat recombinant Cdc42 protein. This sequence is highly conserved in human and mouse Cdc42.

产品描述 :

Cdc42 proteins are Rho GTPase family members, which act as molecular switches in regulating a variety of biological response pathways including cell motility, cell-cycle progression, gene transcription, and cell transformation. Cdc42 GTPases regulate molecular events by cycling from the inactive GDP-bound state to active GTP-bound forms. The ratio of GDP versus GTP, which is bound to the GTPase, is determined by the opposing effects of guanine nucleotide exchange factors and GTPase activating proteins. Active (GTP-bound) Cdc42 binds to the p21-binding domain of p21-activated protein kinase 1 (PAK1) to regulate downstream signaling cascades.

产品引用 :

Munemitsu, S. et al. (1990) Mol. Cell. Biol. 10:5977. Shinjo, K. et al. (1990) PNAS (USA) 87:9853. Erickson, J.W. & Cerione, R.A. (2001) Curr. Opin. Cell. Biol. 13(2):153.

NCBI GI登录号 :

56202836

NCBI登录号 :

CAI19851.1

NCBI基因登录号 :

AL031281.6

UniProt数据库登录号 :

Q5JYX0

NCBI分子量 :

15,180 Da

NCBI信号通路 :

Adaptive Immunity Signaling Pathway 366160!!Adherens Junction Pathway 83070!!Adherens Junction Pathway 481!!Axon Guidance Pathway 83065!!Axon Guidance Pathway 476!!Axon Guidance Pathway 368066!!Axon Guidance Pathway 105688!!Bacterial Invasion Of Epithelial Cells Pathway 149807!!Bacterial Invasion Of Epithelial Cells Pathway 148661!!CD28 Co-stimulation Pathway 119553

NCBI总结 :

The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq]

UniProt数据库总结 :

Sequence similarities: Belongs to the small GTPase superfamily. Rho family. RuleBase RU003317

规格 :

0.1毫升

价格 :

280美元

更多信息或购买 :

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公司信息