产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
神经纤毛蛋白1(a1 CUB区域)
目录 :
MBS472038
规格 :
0.1毫升
价格 :
380美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫细胞化学
更多信息或购买 :
产品信息
目录号 :
MBS472038
产品类型 :
抗体
产品全称 :
神经纤毛蛋白1(a1 CUB区域)
产品简称 :
神经纤毛蛋白1(a1 CUB区域)
产品名称同义词 :
NRP1;血管内皮细胞生长因子165受体
其他名称 :
neuropilin-1 isoform a; Neuropilin-1; neuropilin-1; OTTHUMP00000020818; OTTHUMP00000020819; OTTHUMP00000020820; OTTHUMP00000020821; OTTHUMP00000020822; transmembrane receptor; vascular endothelial cell growth factor 165 receptor; neuropilin 1; Vascular endothelial cell growth factor 165 receptor
其他基因名称 :
NRP1;NRP1;NP1;NRP;BDCA4;CD304;VEGF165R;DKFZp781F1414;DKFZp686A03134;NRP;VEGF165R
UniProt数据库进入名 :
NRP1_HUMAN
克隆性 :
多克隆
宿主 :
反应物种 :
人类, 大鼠, 小鼠
序列长度 :
923
特异性 :
This antibody detects a 130 kDa* protein corresponding to the apparent molecular mass of neuropilin-1 on SDS-PAGE immunoblots of COS-7 cells transfected with mouse neuropilin-1. In immunocytochemistry, this antibody co-localizes with anti-HA in Cos-7 cells transfected with HA-tagged mouse neuropilin-1.
纯度 :
亲和纯化
形式 :
Rabbit polyclonal, affinity-purified antibody is supplied in 100 ul phosphate-buffered saline, 50% glycerol, 1 mg/ml BSA, and 0.05% sodium azide.
储存稳定性 :
Store at -20 degree C. Do not aliquot. Stable for 1 year.
检测过的应用 :
酶联免疫吸附测定, 免疫印迹, 免疫细胞化学
应用笔记 :
ELISA: 1:2000. Immunocytochemistry: 1:50. Western Blot: 1:1000
其它信息1 :
Immunogen: Neuropilin-1 synthetic peptide (coupled to carrier protein) corresponding to amino acids within the a1 CUB domain of human neuropilin-1. This sequence is highly conserved in rat and mouse neuropilin-1, and has low homology to neuropilin-2.
产品描述 :
Neuropilins are transmembrane proteins that contain two CUB domains (a1 and a2), two coagulation factor-like domains (b1 and b2), and a MAM domain in the extracellular region. These proteins have short cytoplasmic domains that include a PDZ-binding motif. The neuropilin (NRP) family includes NRP-1, NRP-2A, and NRP-2B. NRP-1 has been implicated as a receptor involved in axon guidance and VEGF signaling. NRP-1 mediates activation of intracellular signaling pathways through interaction with its coreceptors, Plexin-A1 and VEGFRs. The expression of NRP-1, along with the co-receptor Plexin-A1, is upregulated in neurons after central nervous system injury. The axons from these neurons cannot cross semaphorin 3A-containing regions at the site of injury. Thus, semaphorin 3A and its co-receptors, Plexin-A1 and Neuropilin-1, may have significant roles in axon regeneration after neuronal injury.
产品引用 :
He, Z. & Tessier-Lavigne, M. (1997) Cell 90:739. Nakamura, F. & Goshima, Y. (2002) Adv Exp Med Biol. 515:55. Takahashi, T. et al. (1999) Cell 99:59. Saban, M.R. et al. (2008) Am J Phys Renal Phys 295(1):F60 (ICC: H. Urothelium)
NCBI GI登录号 :
182508169
NCBI登录号 :
NP_003864.4
NCBI基因登录号 :
NM_003873.5
UniProt数据库登录号 :
O14786
NCBI分子量 :
102976 Da
NCBI信号通路 :
Axon Guidance Pathway (83065); Axon Guidance Pathway (476); Axon Guidance Pathway (105688); CHL1 Interactions Pathway (161007); CRMPs In Sema3A Signaling Pathway (119525); HTLV-I Infection Pathway (373901); HTLV-I Infection Pathway (373889); L1CAM Interactions Pathway (161003); Neurophilin Interactions With VEGF And VEGFR Pathway (106509); SEMA3A-Plexin Repulsion Signaling By Inhibiting Integrin Adhesion Pathway (119523)
NCBI总结 :
NRP1 is a membrane-bound coreceptor to a tyrosine kinase receptor for both vascular endothelial growth factor (VEGF; MIM 192240) and semaphorin (see SEMA3A; MIM 603961) family members. NRP1 plays versatile roles in angiogenesis, axon guidance, cell survival, migration, and invasion.[supplied by OMIM]
UniProt数据库总结 :
Function: The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis.The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity. Subunit structure: Homodimer, and heterodimer with NRP2. Binds PLXNB1. Ref.17. Subcellular location: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Tissue specificity: The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules. Domain: The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding. Sequence similarities: Belongs to the neuropilin family.Contains 2 CUB domains.Contains 2 F5/8 type C domains.Contains 1 MAM domain.
尺寸1 :
0.1毫升
价格1 :
380美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。