产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
Anti-Paxillin (Ser-178), phospho-specific
目录 :
MBS472047
规格 :
0.1毫升
价格 :
380美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定
更多信息或购买 :
产品信息
目录号 :
MBS472047
产品类型 :
抗体
产品全称 :
Anti-Paxillin (Ser-178), phospho-specific
产品简称 :
Paxillin (Ser-178)
产品名称同义词 :
Paxillin (Ser-178); phospho-specific; Paxillin
其他名称 :
paxillin; Paxillin; paxillin; myocardial ischemic preconditioning associated protein 7; paxillin
其他基因名称 :
Pxn; Pxn; Pxn
UniProt数据库进入名 :
PAXI_RAT
克隆性 :
多克隆
宿主 :
反应物种 :
人类, 大鼠, 小鼠
序列长度 :
586
特异性 :
This antibody detects a 68kDa* protein corresponding to the molecular mass of phosphorylated paxillin on SDS-PAGE immunoblots of EGF treated A431 cells, but not in A431 control cells. Similar results were seen in calyculin A treated human A431 and aortic endothelial cells.
纯度 :
亲和纯化
形式 :
Rabbit polyclonal, affinity-purified antibody is supplied in 100 ul phosphate-buffered saline, 50% glycerol, 1 mg/ml BSA, and 0.05% sodium azide.
储存稳定性 :
Store at -20 degree C. Do not aliquot. Stable for 1 year.
检测过的应用 :
酶联免疫吸附测定, 免疫印迹
应用笔记 :
ELISA: 1:2000. Western Blot: 1:500
其它信息1 :
Immunogen: Phospho-Paxillin (Ser-178) synthetic peptide (coupled to KLH) corresponding to amino acid residues around serine 178 of human paxillin. This human sequence is highly conserved in rat and mouse paxillin.
产品描述 :
Paxillin, a focal adhesion protein, is involved in focal adhesion formation during cell adhesion and migration. Paxillin contains LD motifs, LIM domains, and SH3-/SH2-binding domains that participate in a variety of protein-protein interactions with kinases, GTPase-activating proteins, and cytoskeletal proteins. Phosphorylation of paxillin occurs at both tyrosine and serine sites. Serine phosphorylation of paxillin occurs in response to growth-factor activation and fibronectins. Both JNK1 and cdc2 kinases can phosphorylate serine 178 in paxillin. The mutant form of paxillin (S178A) decreases the migration of keratocytes and epithelial cells. Thus, phosphorylation paxillin at serine 178 may be important during cell migration.
产品引用 :
Huang, C. et al. (2003) Nature 424:219-223. Huang, C. et al. (2004) Cell Cycle 3(1):4-6. Woodrow, M.A. (2003) Exp. Cell. Res. 287(2):325-338.
NCBI GI登录号 :
58865866
NCBI登录号 :
NP_001012147.1
NCBI基因登录号 :
NM_001012147.1
UniProt数据库登录号 :
Q66H76
NCBI分子量 :
63888 Da
NCBI信号通路 :
Androgen Receptor Signaling Pathway (198529); Bacterial Invasion Of Epithelial Cells Pathway (149774); Bacterial Invasion Of Epithelial Cells Pathway (148661); Chemokine Signaling Pathway (98755); Chemokine Signaling Pathway (96864); EGFR1 Signaling Pathway (198427); Focal Adhesion Pathway (83459); Focal Adhesion Pathway (478); Gab1 Signalosome Pathway (367990); IL-3 Signaling Pathway (198504)
UniProt数据库总结 :
Function: Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Subunit structure: Binds to vinculin, to the SH3 domain of c-SRC and to focal adhesion kinase. Interacts with GIT1 and NUDT16L1/SDOS. Component of cytoplasmic complexes, which also contain GIT1, ARHGEF6 and PAK1. Binds ASAP2 and PDCD10. By similarity. Interacts with PARVA and TGFB1I1. Ref.2 Ref.3. Subcellular location: Cytoplasm cytoskeleton. By similarity. Cell junction focal adhesion. Post-translational modification: Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens. By similarity. Ref.4. Sequence similarities: Belongs to the paxillin family.Contains 4 LIM zinc-binding domains.
尺寸1 :
0.1毫升
价格1 :
380美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。