产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
Anti-Plexin-A1 (Sema Domain)
目录 :
MBS472054
规格 :
0.1毫升
价格 :
380美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫细胞化学, 免疫沉淀
更多信息或购买 :
产品信息
目录号 :
MBS472054
产品类型 :
抗体
产品全称 :
Anti-Plexin-A1 (Sema Domain)
产品简称 :
Plexin A1 (Sema Domain)
产品名称同义词 :
Plexin A1 (Sema Domain); PLXN1; NOV
其他名称 :
plexin A1; cDNA FLJ44113 fis, clone TESTI4046487, highly similar to Mus musculus plexin A1 (Plxna1); plexin-A1; plexin 1; OTTHUMP00000215966; semaphorin receptor NOV; plexin A1
其他基因名称 :
PLXNA1;NOV;NOVP;PLXN1;PLEXIN-A1;DKFZp761P19121
UniProt数据库进入名 :
Q6ZTY7_HUMAN
克隆性 :
多克隆
宿主 :
反应物种 :
人类, 大鼠, 小鼠
序列长度 :
1873
特异性 :
The antibody detects a 220 kDa* protein corresponding to the apparent molecular mass of Plexin-A1 on SDS-PAGE immunoblots of neonatal rat brain lysates and Cos-7 cells transfected with mouse Plexin-A1.
纯度 :
亲和纯化
形式 :
Rabbit polyclonal, affinity-purified antibody is supplied in 100 ul phosphate-buffered saline, 50% glycerol, 1 mg/ml BSA, and 0.05% sodium azide.
储存稳定性 :
Store at -20 degree C. Do not aliquot. Stable for 1 year.
检测过的应用 :
酶联免疫吸附测定, 免疫印迹, 免疫细胞化学, 免疫沉淀
应用笔记 :
ELISA: 1:2000. Immunocytochemistry: 1:100. Immunoprecipitation: 5-10ml. Western Blot: 1:1000
其它信息1 :
Immunogen: Plexin-A1 synthetic peptide (coupled to carrier protein) corresponding to a region within the semaphorin domain in human Plexin-A1. This sequence is highly conserved in rat and mouse Plexin-A1, and has low homology to other Plexin family members.
产品描述 :
Plexins are a family of large integral membrane proteins that complex with neuropilins to form semaphorin co-receptors. The extracellular region of plexins contains a semaphorin domain, multiple glycine-rich motifs, and MET-related sequences. The cytoplasmic region contains a Sex/Plexin domain and putative tyrosine phosphorylation sites that mediate signal transduction after activation. This region in Plexin-A1 binds the RhoGTPases, Rnd1 and RhoD. Recruitment of Rnd1 has been implicated in the cytoskeletal collapse that occurs after semaphorin-mediated activation of Plexin-A1, while RhoD may block this collapsing activity through interaction with the cytoplasmic region of Plexin-A1. The expression of Plexin-A1, along with the co-receptor Neuropilin-1, is upregulated in neurons after central nervous system injury. The axons from these neurons cannot cross semaphorin 3A-containing regions at the site of injury. Thus, semaphorin 3A and its co-receptors, Plexin-A1 and Neuropilin-1, may have significant roles in axon regeneration after neuronal injury.
产品引用 :
Takahashi, T. & Strittmatter, S.M. (2001) Neuron 29:429. Tamagnone, L. et al. (1999) Cell 99:71.
NCBI GI登录号 :
49355818
NCBI登录号 :
NP_115618.2
NCBI基因登录号 :
NM_032242.2
UniProt数据库登录号 :
Q6ZTY7
NCBI分子量 :
208419 Da
NCBI信号通路 :
Axon Guidance Pathway 83065!!Axon Guidance Pathway 476!!Axon Guidance Pathway 366334!!Axon Guidance Pathway 105688!!CRMPs In Sema3A Signaling Pathway 119525!!Other Semaphorin Interactions Pathway 119526!!SEMA3A-Plexin Repulsion Signaling By Inhibiting Integrin Adhesion Pathway 119523!!Sema3A PAK Dependent Axon Repulsion Pathway 119524!!Sema3A PAK Dependent Axon Repulsion Pathway 366340!!Semaphorin Interactions Pathway 119519
规格 :
0.1毫升
价格 :
380美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。