产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
SHP1 (Tyr-536), phospho-specific
目录 :
MBS472062
规格 :
0.1毫升
价格 :
380美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
抗原修饰 :
磷酸化
应用 :
免疫印迹, 酶联免疫吸附测定
更多信息或购买 :
产品信息
目录号 :
MBS472062
产品类型 :
抗体
产品全称 :
SHP1 (Tyr-536), phospho-specific
产品简称 :
SHP1 (Tyr-536)
产品名称同义词 :
PTP-1C;蛋白酪氨酸磷酸酶 1C;SH-PTP1;SHP-1
克隆性 :
多克隆
宿主 :
反应物种 :
人类, 大鼠, 小鼠
特异性 :
This antibody was cross-adsorbed to a non-specific phospho-tyrosine peptide then affinity-purified using phospho-SHP1 (Tyr-536) peptide. The antibody detects a 68 kDa* band on SDS-PAGE immunoblots of human Jurkat cells treated with pervanadate, but is not observed in control cells.
纯度 :
亲和纯化
形式 :
Rabbit polyclonal, affinity-purified antibody is supplied in 100 ul phosphate-buffered saline, 50% glycerol, 1 mg/ml BSA, and 0.05% sodium azide.
储存稳定性 :
Store at -20 degree C. Do not aliquot. Stable for 1 year.
检测过的应用 :
酶联免疫吸附测定, 免疫印迹
应用笔记 :
ELISA: 1:2000. Western Blot: 1:1000
其它信息1 :
Immunogen: Phospho-SHP1 (Tyr-536) synthetic peptide (coupled to carrier protein) corresponding to amino acids around tyrosine 536 in human SHP1. The sequence is highly conserved in rat and mouse SHP1.
产品描述 :
SHP1 (PTP1C, SH-PTP1, or HCP) is a protein-tyrosine phosphatase (PTP) involved in cell migration, cell proliferation, and immune cell function. This phosphatase contains two N-terminal SH2 domains and a C-terminal phosphatase domain. SHP1 associates with a variety of cytokine and growth factor receptors and regulates signal transduction through dephosphorylation of these receptors or their downstream effectors. Downstream of receptor activation, SHP1 regulates the transcriptional activity stimulated by JAK/Stat and MAPK pathways. SHP1 activity is regulated by both tyrosine and serine phosphorylation. Phosphorylation of Tyr-536 and Tyr-564 stimulates phosphatase activity and promotes interaction with Grb-2. Serine phosphorylation at Ser-591 is mediated by PKC-alpha and leads to inhibition of phosphatase activity. Thus, phosphorylation at tyrosine relative to serine residues may be regulated by different cell signaling pathways to control SHP1 activity.
产品引用 :
Jones, M.L. et al. (2004) J. Biol. Chem. 279(39):40475. Zhang, Z. et al. (2003) J. Biol. Chem. 278(7):4668. Zhang, J. et al. (2000) Semin. Immunol. 12:361.
尺寸1 :
0.1毫升
价格1 :
380美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。