产品简要
公司名称 :
MyBioSource
产品类型 :
蛋白
产品名称 :
VE钙粘蛋白(氨基酸770-781)肽
目录 :
MBS474068
规格 :
0.05毫克
价格 :
130美元
更多信息或购买 :
产品信息
目录号 :
MBS474068
产品类型 :
多肽
产品全称 :
VE钙粘蛋白(氨基酸770-781)肽
产品简称 :
VE钙粘蛋白(a.a。 770-781)
产品名称同义词 :
VE钙粘蛋白(a.a。 770-781)
其他名称 :
VE-cadherin; Cadherin-5; cadherin-5; 7B4 antigen; VE-cadherin; cd144 antigen; OTTHUMP00000174777; endothelial-specific cadherin; vascular endothelial cadherin; cadherin 5, type 2, VE-cadherin (vascular epithelium); cadherin 5, type 2 (vascular endothelium); 7B4 antigen; Vascular endothelial cadherin
其他基因名称 :
血管内皮钙粘蛋白;血管内皮钙粘蛋白;7B4;CD144;FLJ17376
UniProt数据库进入名 :
CADH5_HUMAN
序列 :
Peptide Sequence: VE-Cadherin synthetic peptide corresponds to amino acids 770 to 781 in human VE-cadherin. This sequence has significant homology to the conserved site in rat and mouse, and has less than 50% homology with other cadherins.
特异性 :
This peptide is specifically recognized by VE-cadherin (a. a. 770-781) antibody (CP2231) in ELISA, and has been shown to block the reactivity of CP2231 in Western blot and is recommended for blocking in immunocytochemistry.
形式 :
Blocking Peptide is supplied in 50ul phosphate-buffered saline and 0.05% sodium azide.
储存稳定性 :
Store at -20 degree C. Stable for 1 year.
应用笔记 :
Blocking: 1:1,000. ELISA: 50 ng/well
产品描述 :
Cadherins are transmembrane glycoproteins vital in calcium-dependent cell-cell adhesion during tissue differentiation. Cadherins cluster to form foci of homophilic binding units. A key determinant to the strength of the cadherin-mediated adhesion may be by the juxtamembrane region in cadherins. VE-cadherin (Cadherin 5) is the major cadherin found in endothelial cells and has important roles during angiogenesis and maintenance of barrier permeability. The cytoplasmic domain of VEcadherin comprises the juxtamembrane domain that binds to the p120 catenin, and the carboxylterminal domain that interacts with beta or gamma catenins. Modulation of tyrosine phosphorylation on one or more of the nine tyrosine sites in the cytoplasmic domain may be important for regulating both angiogenesis and permeability. Phosphorylation of Tyr -658 and Tyr-731 alters catenin binding, restores cell migration, and decreases barrier permeability. While VEGF-induced phosphorylation of Tyr-685 occurs through c-Src, and regulates endothelial cell migration, but not permeability.
产品引用 :
Potter M.D. et al. (2005) J Biol. Chem. 280(36):31906. Baumeister U. et al. (2005) EMBOJ 24:1686. Wallez Y. et al. (2007) Oncogene 26:1067
NCBI GI登录号 :
599834
UniProt数据库登录号 :
P33151
NCBI分子量 :
87,528 Da
NCBI信号通路 :
Adherens Junctions Interactions Pathway 119533!!Cell Adhesion Molecules (CAMs) Pathway 83069!!Cell Adhesion Molecules (CAMs) Pathway 480!!Cell Junction Organization Pathway 160966!!Cell-cell Junction Organization Pathway 119532!!Leukocyte Transendothelial Migration Pathway 83083!!Leukocyte Transendothelial Migration Pathway 494!!S1P2 Pathway 138059!!Signaling Events Mediated By VEGFR1 And VEGFR2 Pathway 137940
NCBI总结 :
This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq]
UniProt数据库总结 :
Function: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction. Ref.9. Subunit structure: Interacts via cadherin 5 domain with PTPRB. By similarity. Interacts with TRPC4. Interacts with KRIT1. Ref.8 Ref.9. Subcellular location: Cell junction. Cell membrane; Single-pass type I membrane protein. Probable. Note: Found at cell-cell boundaries and probably at cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions. Ref.9. Tissue specificity: Endothelial tissues and brain. Post-translational modification: Phosphorylated on tyrosine residues by KDR/VEGFR-2. Dephosphorylated by PTPRB. By similarity. Ref.7. Sequence similarities: Contains 5 cadherin domains.
规格 :
0.05毫克
价格 :
130美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。