产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
抗FLT3小鼠单克隆抗体
目录 :
MBS476418
规格 :
0.1毫升
价格 :
335美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
[7B7C3]
反应物种 :
人类
应用 :
免疫印迹, 免疫组化
更多信息或购买 :
图像
图像 1 :
Western blot analysis using FLT3 mAb against human FLT3 recombinant protein. (Expected MW is 32.6 kDa)
图像 2 :
Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using FLT3 mouse mAb with DAB staining.
图像 3 :
Immunohistochemical analysis of paraffin-embedded liver cancer tissues using FLT3 mouse mAb with DAB staining.
产品信息
目录号 :
MBS476418
产品类型 :
抗体
产品全称 :
抗FLT3小鼠单克隆抗体
产品简称 :
[FLT3]
产品名称同义词 :
[FLK2;STK1;CD135;FLK-2]
其他名称 :
[FLT3 receptor tyrosine kinase; Receptor-type tyrosine-protein kinase FLT3; receptor-type tyrosine-protein kinase FLT3; fms related tyrosine kinase 3; FL cytokine receptor; Fetal liver kinase-2; FLK-2; Fms-like tyrosine kinase 3; FLT-3; Stem cell tyrosine kinase 1; STK-1; CD_antigen: CD135]
产品基因名称 :
[FLT3]
产品基因名称同义词 :
[FLK2;STK1;CD135;FLK-2]
其他基因名称 :
[FLT3;FLT3;FLK2;STK1;CD135;FLK-2;CD135;FLK2;STK1;FLK-2;FLT-3;STK-1]
克隆性 :
单克隆
抗体亚型 :
IgG1
克隆 :
[7B7C3]
宿主 :
小鼠
反应物种 :
人类
序列长度 :
993
纯度 :
亲和纯化
形式 :
Purified antibody in PBS with 0.05% sodium azide
储存稳定性 :
Store at 4°C short term. Store at -20°C long term. Avoid freeze/thaw cycle.
检测过的应用 :
免疫印迹(免疫印迹), 免疫组化(免疫组化)
应用笔记 :
免疫印迹:1/500-1/2000。 IHC:1/200-1/1000。 ELISA: 1/10000
image1头 :
免疫印迹(免疫印迹)
image2头 :
免疫组化(免疫组化)
image3头 :
免疫组化(免疫组化)
其它信息1 :
Antibody type: Primary Antibody. Conjugation: Unconjugated. Immunogen: Purified recombinant fragment of human FLT3 (AA: 930-991) expressed in E Coli. Modification: Unmodification
产品描述 :
This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
NCBI GI登录号 :
406323
NCBI登录号 :
CAA81393.1
NCBI分子量 :
130 kDa
NCBI信号通路 :
Acute Myeloid Leukemia Pathway (83117); Acute Myeloid Leukemia Pathway (529); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); Pathways In Cancer (83105); Transcriptional Misregulation In Cancer Pathway (523016); Transcriptional Misregulation In Cancer Pathway (522987)
NCBI总结 :
This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015]
UniProt数据库总结 :
FLT3: a receptor tyrosine kinase of the PDGFR family that binds the FL cytokine. FLT3 -/- mice have an impaired developmental capacity of primitive hematopoietic progenitor cells of all lineages with the greatest impact on lymphopoietic precursors. Activating mutations found in one third of cases of acute myeloid leukemia (AML), as well as in acute lymphoblastic leukemia, acute promyelocytic leukemia and myelodysplastic syndrome. Inhibitors: Sutent and PKC412. Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Oncoprotein; PDGFR family; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group. Chromosomal Location of Human Ortholog: 13q12.2. Cellular Component: integral to plasma membrane; plasma membrane. Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; protein homodimerization activity; transmembrane receptor protein tyrosine kinase activity; vascular endothelial growth factor receptor activity. Biological Process: B cell differentiation; cytokine and chemokine mediated signaling pathway; hemopoiesis; leukocyte homeostasis; lymphocyte proliferation; myeloid progenitor cell differentiation; peptidyl-tyrosine phosphorylation; positive regulation of cell proliferation; positive regulation of MAP kinase activity; positive regulation of MAPKKK cascade; positive regulation of phosphoinositide 3-kinase activity; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of tyrosine phosphorylation of STAT protein; pro-B cell differentiation; protein amino acid autophosphorylation; regulation of apoptosis; transmembrane receptor protein tyrosine kinase signaling pathway. Disease: Leukemia, Acute Lymphoblastic
尺寸1 :
0.1毫升
价格1 :
335美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华，公司愿景是“生物研究试剂的源头”，现在位于圣地亚哥市。