产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
抗cPLA2, 小鼠多克隆
目录 :
MBS480031
规格 :
1毫克
价格 :
485美元
克隆性 :
多克隆
宿主 :
小鼠
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫印迹
更多信息或购买 :
产品信息
目录号 :
MBS480031
产品类型 :
抗体
产品全称 :
抗cPLA2, 小鼠多克隆
产品简称 :
cPLA2
产品名称同义词 :
抗小鼠cPLA2
其他名称 :
cytosolic phospholipase A2; Cytosolic phospholipase A2; cytosolic phospholipase A2; cPLA2; calcium-dependent phospholipid-binding protein; lysophospholipase; phosphatidylcholine 2-acylhydrolase; phospholipase A2 group IVA; phospholipase A2, group IVA (cytosolic, calcium-dependent); Phospholipase A2 group IVAIncluding the following 2 domains:Phospholipase A2 (EC:3.1.1.4)Alternative name(s):Phosphatidylcholine 2-acylhydrolase
产品基因名称 :
cPLA2
其他基因名称 :
PLA2G4A;PLA2G4A;PLA2G4;cPLA2甲;CPLA2;PLA2G4;cPLA2
UniProt数据库进入名 :
PA24A_HUMAN
克隆性 :
多克隆
抗体亚型 :
IgG
宿主 :
小鼠
序列长度 :
749
特异性 :
小鼠
纯度 :
Ammonium Sulfate Fractionation
浓度 :
1毫克/毫升
储存稳定性 :
At -70 degree C. AVOID REPEATED FREEZE THAW CYCLES. Has demonstrated stability at 4 degree C for greater than 1 month., Phosphate Buffered Saline; 0.05% Sodium Azide
检测过的应用 :
免疫印迹(免疫印迹)
应用笔记 :
Western Blot: 1-5 mug/mL
其它信息1 :
Storage Buffer: Phosphate Buffered Saline; 0.05% Sodium Azide. Procedural Notes: Yields a positive response with 10 mug of Raw cell line using alkaline phosphatase detection method.
产品描述 :
Description: This polyclonal antibody is produced in rabbit and is provided as an IgG preparation specific for cytosolic Phospholipase A2 (cPLA2).
产品引用 :
Channon, JY et al. JBC, 265: 5409-5413 (1990) Kramer, RM et al. JBC, 270: 14816-14823 (1995) Clark, JD et al. Cell, 65(6): 1043-1051 (1991)
NCBI GI登录号 :
23943920
NCBI登录号 :
NP_077734.1
NCBI基因登录号 :
NM_024420.2
UniProt数据库登录号 :
P47712
NCBI分子量 :
85 kDa
NCBI信号通路 :
ADP Signalling Through P2Y Purinoceptor 1 Pathway (161061); AGE/RAGE Pathway (698754); Acyl Chain Remodeling Of CL Pathway (645330); Acyl Chain Remodelling Of PC Pathway (645321); Acyl Chain Remodelling Of PE Pathway (645317); Acyl Chain Remodelling Of PG Pathway (645328); Acyl Chain Remodelling Of PI Pathway (645326); Acyl Chain Remodelling Of PS Pathway (645324); Arachidonic Acid Metabolism Pathway (82991); Arachidonic Acid Metabolism Pathway (685553)
NCBI总结 :
This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
cPLA2: a calcium-dependent phospholipase A2 that catalyzes the release of arachidonic acid from membrane phospholipids. Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Arachidonic acid is a precursor for the eicosanoids that are involved in hemodynamic regulation, inflammatory responses, and other cellular processes. Promotes cerebellar long-term depression and motor learning. Translocates to the Golgi and endoplasmic reticulum in a calcium-dependent fashion. Translocation and activation of at the ER facilitates the process of ER stress. Regulates the biogenesis of lipid droplets, a process dependent on JNK and ceramide kinase. Stimulated by agonists such as ATP, EGF, thrombin and bradykinin as well as by cytosolic Ca2+. The N-terminal C2 domain, by its association with lipid membranes, mediates the regulation of CPLA2 by presenting the active site to its substrate in response to elevations of cytosolic Ca2+. Inhibited when in trimolecular complex with ANXA2 and S100A10. Phosphorylation of S727 relieves this inhibitory interaction, thus activating PLA2G4A. Protein type: Lipid Metabolism - glycerophospholipid; Lipid Metabolism - ether lipid; Lipid Metabolism - linoleic acid; EC 3.1.1.4; EC 3.1.1.5; Lipid Metabolism - arachidonic acid; Lipid Metabolism - alpha-linolenic acid; Phospholipase. Chromosomal Location of Human Ortholog: 1q25. Cellular Component: Golgi apparatus; endoplasmic reticulum membrane; cytoplasmic membrane-bound vesicle; cytoplasm; mitochondrial inner membrane; cytosol. Molecular Function: phospholipase A2 activity; calcium-dependent phospholipid binding; calcium-dependent phospholipase A2 activity; calcium ion binding; lysophospholipase activity. Biological Process: icosanoid biosynthetic process; platelet activation; platelet activating factor biosynthetic process; phospholipid catabolic process; phospholipid metabolic process; icosanoid metabolic process; glycerophospholipid biosynthetic process; phosphatidic acid biosynthetic process; arachidonic acid metabolic process; arachidonic acid secretion; blood coagulation; regulation of cell proliferation
尺寸1 :
1毫克
价格1 :
485美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。