Estrogen receptor beta; 5p152; estrogen receptor beta; estrogen receptor beta 4; nuclear receptor subfamily 3 group A member 2; estrogen receptor 2 (ER beta); 5p152
ESR2; ESR2; Erb; ESRB; ESTRB; NR3A2; ER-BETA; ESR-BETA
Human ERbeta, not tested on other species.
Store at -20 degree C. Avoid repeating freeze/thaw cycles, as it may result in loss of activity.
Suggested starting concentration for Western blots is 1.0 g/mL. Not tested for IHC or ELISA.
Immunogen: Recombinant Human Erbeta
NCBI GI登录号 :
Predicted: 53 kDa
Estrogen Signaling Pathway (799177); Estrogen Signaling Pathway (799197); Gene Expression Pathway (105937); Generic Transcription Pathway (105938); Integrated Pancreatic Cancer Pathway (711360); Nuclear Receptor Transcription Pathway (105979); Nuclear Receptors Pathway (198848); Ovarian Infertility Genes Pathway (198801); Plasma Membrane Estrogen Receptor Signaling Pathway (138009); Prolactin Signaling Pathway (814182)
This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]
ER-beta: a nuclear hormone receptor and transcription factor. Binds and activated by estrogen. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Eight alternatively-spliced isoforms have been described. Isoform beta-cx lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability. Protein type: DNA-binding; Nuclear receptor. Chromosomal Location of Human Ortholog: 14q23.2. Cellular Component: nucleoplasm; mitochondrion; extracellular region; nucleus. Molecular Function: receptor antagonist activity; protein binding; ligand-dependent nuclear receptor activity; estrogen receptor activity; enzyme binding; DNA binding; zinc ion binding; transcription coactivator activity; estrogen response element binding; steroid hormone receptor activity; transcription factor activity; steroid binding. Biological Process: transcription initiation from RNA polymerase II promoter; estrogen receptor signaling pathway; induction of apoptosis by hormones; neuron migration; vagina development; negative regulation of transcription from RNA polymerase II promoter; uterus development; signal transduction; cell-cell signaling; ovarian follicle development; regulation of transcription, DNA-dependent; steroid hormone mediated signaling; gene expression; positive regulation of transcription factor activity; negative regulation of cell growth; brain development; negative regulation of epithelial cell proliferation
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308