产品简要
公司名称 :
MyBioSource
产品类型 :
ELISA/assay
产品名称 :
p53(人类)酶联免疫吸附测定
目录 :
MBS494528
规格 :
96试验
价格 :
680美元
更多信息或购买 :
产品信息
目录号 :
MBS494528
产品类型 :
酶联免疫吸附试剂盒
产品全称 :
p53(人类)酶联免疫吸附测定
产品简称 :
p53
其他名称 :
P53; Cellular tumor antigen p53; cellular tumor antigen p53; antigen NY-CO-13; mutant tumor protein 53; p53 tumor suppressor; phosphoprotein p53; transformation-related protein 53; tumor protein p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53
产品基因名称 :
p53
其他基因名称 :
TP53;TP53;P53;BCC7;LFS1;TRP53;P53
UniProt数据库进入名 :
P53_HUMAN
序列长度 :
393
产品描述 :
Intended Use The human p53 ELISA is an enzyme-linked immunosorbent assay for the detection of human p53. For research use only, not for use in diagnostic procedures. PRINCIPLE OF THE TEST An anti-human p53 coating antibody is adsorbed onto microwells. Human p53 present in the unknown or calibrator binds to antibodies adsorbed to the microwells. A biotin-conjugated anti-human p53 antibody is added and binds to human p53 captured by the first antibody. Following incubation unbound biotin-conjugated anti-human p53 antibody is removed during a wash step. Streptavidin-HRP is added and binds to the biotin-conjugated anti-human p53 antibody. Following incubation unbound Streptavidin-HRP is removed during a wash step, and substrate solution reactive with HRP is added to the wells. A coloured product is formed in proportion to the amount of human p53 present in the unknown orcalibrator. The reaction is terminated by addition of acid and absorbance is measured at 450 nm. A calibrator curve is prepared from 7 human p53 calibrator dilutions and human p53 unknown concentration determined.
NCBI GI登录号 :
23491729
NCBI登录号 :
BAC16799.1
UniProt数据库登录号 :
P04637
NCBI分子量 :
24,401 Da
NCBI信号通路 :
AMPK Signaling Pathway 198868!!Activation Of BH3-only Proteins Pathway 105658!!Activation Of NOXA And Translocation To Mitochondria Pathway 105660!!Activation Of PUMA And Translocation To Mitochondria Pathway 105661!!Alzheimers Disease Pathway 672448!!Amyotrophic Lateral Sclerosis (ALS) Pathway 920975!!Amyotrophic Lateral Sclerosis (ALS) Pathway 83099!!Amyotrophic Lateral Sclerosis (ALS) Pathway 511!!Apoptosis Pathway 198797!!Apoptosis Pathway 83060
NCBI总结 :
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013]
规格 :
96试验
价格 :
680美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。