产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
抗PSD-95
目录 :
MBS502106
规格 :
0.1毫升
价格 :
345美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
大鼠
应用 :
免疫印迹
更多信息或购买 :
产品信息
目录号 :
MBS502106
产品类型 :
抗体
产品全称 :
抗PSD-95
产品简称 :
PSD-95
其他名称 :
disks large homolog 4; Disks large homolog 4; disks large homolog 4; PSD-95; SAP-90; discs large homolog 4; synapse-associated protein 90; postsynaptic density protein 95; synapse-associated protein SAP90; discs, large homolog 4 (Drosophila); Postsynaptic density protein 95; PSD-95; Synapse-associated protein 90
产品基因名称 :
DLG4
其他基因名称 :
Dlg4;Dlg4;Dlgh4;PSD95;Sap90;Dlgh4;Psd95;PSD-95;SAP-90;SAP90
UniProt数据库进入名 :
DLG4_RAT
克隆性 :
多克隆
宿主 :
反应物种 :
大鼠
序列长度 :
724
纯度 :
Affinity Purified (Specific for ~95k PSD-95 protein.)
形式 :
100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.
储存稳定性 :
Store at -20 degree C; stable for at least one year.
检测过的应用 :
免疫印迹(免疫印迹)
应用笔记 :
Quality Control: Western blots performed on each lot. WB: 1:1000
其它信息1 :
Antigen: Peptide corresponding to amino acid residues from the N-terminal region of rat PSD-95, conjugated to keyhole limpet hemocyanin (KLH). Immunogen Information: Synthetic peptide corresponding to amino acid residues from the N-terminal region conjugated to KLH. Immunogen Species: Rat
其他信息2 :
Reactivity Assumed Based on 100% Sequence Homology: Bovine, human, mouse, non-human primates and zebra fish. Species Reactivity Note: The antibody has been directly tested for reactivity in Western blots in rat and mouse tissues. It is anticipated that the antibody will also work with bovine, human, non-human primates and zebra fish tissues based on the fact that these species have 100% homology with the amino acid sequence used as antigen. Biological Significance: PSD-95 is a very prominent component of the postsynaptic densities of synapses. It contains three PDZ domains which play key roles in its interactions with other proteins in the synapse. It has been proposed that these PDZ domains organize glutamate receptors and their associated signaling proteins and determine the size and strength of synapses (Kim and Sheng, 2004). Recent work suggests that interaction of the NMDAR with PSD-95 via these PDZ domains can be regulated by phosphorylation (Chung et al., 2004).
产品描述 :
亲和纯化兔多克隆抗体
产品引用 :
Chung HJ, Huang YH, Lau LF, Huganir RL (2004) Regulation of the NMDA receptor complex and trafficking by activity-dependent phosphorylation of the NR2B subunit PDZ ligand. J Neurosci 24:10248-10259. Kim EJ, Sheng M (2004) PDZ domain proteins of synapses. Nat Rev Neurosci 5:771-781.
NCBI GI登录号 :
9665227
NCBI登录号 :
NP_062567.1
NCBI基因登录号 :
NM_019621.1
UniProt数据库登录号 :
P31016
NCBI分子量 :
95
NCBI信号通路 :
Activation Of Ca-permeable Kainate Receptor Pathway (936458); Activation Of Kainate Receptors Upon Glutamate Binding Pathway (936455); Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway (936445); Axon Guidance Pathway (936266); CREB Phosphorylation Through The Activation Of CaMKII Pathway (936452); CREB Phosphorylation Through The Activation Of Ras Pathway (936448); Cocaine Addiction Pathway (546271); Cocaine Addiction Pathway (546273); Developmental Biology Pathway (936265); Glutamatergic Synapse Pathway (213815)
NCBI总结 :
a molecular scaffolding protein that binds and clusters N-methyl-D-aspartate receptors at neuronal synapses; may be involved in guanine nucleotide-mediated signal transduction pathway [RGD, Feb 2006]
UniProt数据库总结 :
Function: Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Ref.17 Ref.19 Ref.27. Subunit structure: Interacts through its PDZ domains with ANO2 and NETO1. Interacts through its first two PDZ domains with GRIN2A, GRIN2B, GRIN2C, GRIN2D, ASIC3, certain splice forms of GRIN1, KCND2, CXADR, SYNGAP1, KCNA1, KCNA2, KCNA3, KCNA4, ERBB4, LRRC4; LRRC4B and SEMA4C. Interacts through its first PDZ domain with GRIK2, KCNA4 and CRIPT. Interacts through its second PDZ domain with the PDZ domain of NOS1 or the C-terminus of CAPON. Interacts through its third PDZ domain with NLGN1 and CRIPT, and probably with NLGN2 and NLGN3. Interacts through its guanylate kinase-like domain with DLGAP1/GKAP, DLGAP2, DLGAP3, DLGAP4, MAP1A, BEGAIN, SIPA1L1 and KIF13B. Isoform 2 interacts through an L27 domain with HGS/HRS and the first L27 domain of CASK. Interacts with ADR1B, ANKS1B and PRR7. May interact with HTR2A. Interacts with ADAM22, KLHL17 and LGI1. Interacts with FRMPD4 (via C-terminus). Interacts with LRFN1, LRFN2 and LRFN4, but not with LRFN3 nor LRFN5. Interacts (via N-terminus tandem pair of PDZ domains) with GPER1 (via C-terminus tail motif); the interaction is direct and induces the increase of GPER1 protein levels residing at the plasma membrane surface in a estradiol-independent manner. Interacts (via N-terminus tandem pair of PDZ domains) with NOS1 (via N-terminus domain). Interacts with SHANK3. Subcellular location: Cell membrane; Peripheral membrane protein. Cell junction synapse postsynaptic cell membrane postsynaptic density. Cell junction synapse. Note: High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells. Ref.6 Ref.7 Ref.14. Tissue specificity: Detected in brain (at protein level). Brain. Highest levels of isoform 2 in cerebellum, cortex, hippocampus, and corpus striatum. Ref.14 Ref.16. Domain: The PDZ domain 3 mediates interaction with ADR1B . By similarity.The L27 domain near the N-terminus of isoform 2 is required for HGS/HRS-dependent targeting to postsynaptic density . By similarity. Post-translational modification: Palmitoylation of isoform 1 is required for targeting to postsynaptic density. Ref.12. Sequence similarities: Belongs to the MAGUK family.Contains 1 guanylate kinase-like domain.Contains 3 PDZ (DHR) domains.Contains 1 SH3 domain.
尺寸1 :
0.1毫升
价格1 :
345美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。