抗体

Anti-Mouse CD8a (Ly 2) Biotin (Clone CT-CD8a) (rat IgG2a)

MBS520208

0.1毫克

295美元

单克隆

大鼠

生物素

CT-CD8a

人类, 小鼠

免疫组化, 流式细胞仪, 流式细胞仪

抗体

Anti-Mouse CD8a (Ly 2) Biotin (Clone CT-CD8a) (rat IgG2a)

CD8a (Ly 2)

CD8a (Ly 2) Biotin (Clone CT-CD8a) (rat IgG2a); Anti-Mouse CD8a Antigen Monoclonal Antibody

CD8a molecule; T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein CD8 alpha chain; T8 T-cell antigen; T cell co-receptor; OKT8 T-cell antigen; T-cell antigen Leu2; Leu2 T-lymphocyte antigen; CD8 antigen, alpha polypeptide (p32); T-lymphocyte differentiation antigen T8/Leu-2; CD8a molecule; T-lymphocyte differentiation antigen T8/Leu-2

CD8a (Ly 2)

CD8A;CD8A;CD8;MAL;p32;Leu2;MAL

CD8A_HUMAN

单克隆

大鼠IgG2a

CT-CD8a

大鼠

小鼠

235

CD8a (Ly 2; Lyt 2) (Mouse CD8a)

生物素

0.1毫克/毫升

For all formats, store at 4 degree C. DO NOT FREEZE APC, PE and TC conjugates. For long term storage (Purified, Biotin and FITC), aliquot and freeze unused portion at -20 degree C in volumes appropriate for single usage. Avoid freeze/thaw cycles.

免疫组化(免疫组化), 流式细胞仪(FC/流式细胞仪)

Presentation: Biotin/FITC/PE/APC/TC conjugated IgG buffered in PBS, 0.02% NaN3 and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/mL.

anti-mouse CD8a antigen monoclonal antibody binds to a protein of approximately 30,000 daltons found on 85% of mouse thymocytes, mouse cytotoxic/suppressor T cells and their precursors. It does not bind to mouse helper/inducer T cells. This antibody is not strain specific and can be used with all commonly used laboratory mice. This antibody is suitable for use in flow cytometry, in vivo assays and immunohistochemistry (Frozen and paraffinembedded sections).

19344022

AAH25715.1

P01732

25,729 Da

Adaptive Immune System Pathway (366160); Antigen Processing And Presentation Pathway (83074); Antigen Processing And Presentation Pathway (485); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Downstream Signaling In Naive CD8+ T Cells Pathway (138018); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); IL12-mediated Signaling Events Pathway (137922); Immune System Pathway (106386)

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Function: Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains. Subunit structure: In general heterodimer of an alpha and a beta chain linked by two disulfide bonds. Can also form homodimers. Shown to be expressed as heterodimer on thymocytes and as homodimer on peripheral blood T-lymphocytes. Interacts with the MHC class I HLA-A/B2M dimer. Interacts with LCK in a zinc-dependent manner. Ref.9. Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Post-translational modification: All of the five most C-terminal cysteines form inter-chain disulfide bonds in dimers and higher multimers, while the four N-terminal cysteines do not . By similarity. Involvement in disease: Familial CD8 deficiency (CD8 deficiency) [MIM:608957]: Novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.Note: The disease is caused by mutations affecting the gene represented in this entry. Sequence similarities: Contains 1 Ig-like V-type (immunoglobulin-like) domain.

0.1毫克

295美元

0.3毫克

530