产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
Anti-Human CTLA-4, Purified, (clone: A3.4H2.H12), (mouse IgG2ak)
目录 :
MBS520259
规格 :
0.25毫克
价格 :
340美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
A3.4H2.H12
反应物种 :
人类
应用 :
流式细胞仪
更多信息或购买 :
产品信息
目录号 :
MBS520259
产品类型 :
抗体
产品全称 :
Anti-Human CTLA-4, Purified, (clone: A3.4H2.H12), (mouse IgG2ak)
产品简称 :
CTLA-4
产品名称同义词 :
CTLA-4, Purified, (clone: A3.4H2.H12), (mouse IgG2ak); Purified Anti-Human CTLA-4 (CD152) Monoclonal Antibody
其他名称 :
cytotoxic T-lymphocyte protein 4 isoform CTLA4-TM; Cytotoxic T-lymphocyte protein 4; cytotoxic T-lymphocyte protein 4; CD152 isoform; celiac disease 3; cytotoxic T-lymphocyte antigen 4; cytotoxic T-lymphocyte-associated antigen 4; cytotoxic T-lymphocyte-associated serine esterase-4; cytotoxic T lymphocyte associated antigen 4 short spliced form; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4; cytotoxic T-lymphocyte-associated protein 4; Cytotoxic T-lymphocyte-associated antigen 4
产品基因名称 :
CTLA-4
其他基因名称 :
CTLA4;CTLA4;Coding sequence蛋白质编码序列;GSE;GRD4;CD152;CTLA-4;IDDM12;CELIAC3;CD152;CTLA-4
UniProt数据库进入名 :
CTLA4_HUMAN
克隆性 :
单克隆
抗体亚型 :
小鼠IgG2akappa
克隆 :
A3.4H2.H12
宿主 :
小鼠
反应物种 :
人类
序列长度 :
223
特异性 :
CTLA4(人类CTLA-4(CD152))
形式 :
Purified (Purified IgG buffered in PBS and 0.02% NaN3 (Purified from ascitic fluid via Protein G Chromatography). For maximum recovery of contents, spin down tube before use.
浓度 :
Antibody Concentration: 1.0 mg/ml
储存稳定性 :
Store at 4 degree C. For long term storage, aliquot and freeze unused portion at -20 degree C in volumes appropriate for single usage. Avoid freeze/thaw cycles.
检测过的应用 :
流式细胞仪(FC)
其它信息1 :
Immunogen: Activated T cells. Donor: Balb/c mouse. Fusion Partner: SP 2/0 myeloma
其他信息2 :
Presentation: 250 ug purified IgG buffered in PBS and 0.02% NaN3. (Purfied fro ascitic fluid via Protein G Chromatography). For maximum recovery of contents, spin down tube before use.
产品描述 :
Human CTLA-4 (also known as Cytotoxic T lymphocyte-associated antigen-4, CD152) is a structural homologue of T cell co-stimulatory receptor CD28. CTLA-4 binds to the same ligands (CD80 and CD86) as CD28 but with much higher avidity. It is expressed at very low levels on the cell surface of activated T cells, and is found primarily in the post-Golgi or endosomal compartments of the cell. There is a high degree of overall homology between human and mouse CTLA-4 (>70%), and the cytoplasmic domains of the human, mouse and rabbit sequences are completely conserved. CD152 antibodies have shown both stimulatory and negative regulatory roles in functional experiments. This antibody is suitable for use in flow cytometry.
NCBI GI登录号 :
21361212
NCBI登录号 :
NP_005205.2
NCBI基因登录号 :
NM_005214.4
UniProt数据库登录号 :
P16410
NCBI信号通路 :
Adaptive Immune System Pathway (366160); Autoimmune Thyroid Disease Pathway (83121); Autoimmune Thyroid Disease Pathway (533); CTLA4 Inhibitory Signaling Pathway (119556); Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway (137993); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Costimulation By The CD28 Family Pathway (119552); Immune System Pathway (106386); Rheumatoid Arthritis Pathway (200309)
NCBI总结 :
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
Function: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. Ref.11 Ref.17. Subunit structure: Homodimer; disulfide-linked. Binds to CD80/B7-1 and CD86/B7.2. Ref.21 Ref.22 Ref.23. Subcellular location: Cell membrane; Single-pass type I membrane protein. Note: Exists primarily an intracellular antigen whose surface expression is tightly regulated by restricted trafficking to the cell surface and rapid internalisation;. Ref.18. Tissue specificity: Widely expressed with highest levels in lymphoid tissues. Detected in activated T-cells where expression levels are 30- to 50-fold less than CD28, the stimulatory coreceptor, on the cell surface following activation. Ref.1 Ref.10 Ref.17. Post-translational modification: N-glycosylation is important for dimerization.Phosphorylation at Tyr-201 prevents binding to the AP-2 adapter complex, blocks endocytosis, and leads to retention of CTLA4 on the cell surface. Polymorphism: Genetic variations in CTLA4 are associated with susceptibility to several autoimmune disorders. They influence responsiveness to hepatitis B virus (HBV) infection [. MIM:610424]. Involvement in disease: Systemic lupus erythematosus (SLE) [MIM:152700]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.27Genetic variations in CTLA4 may influence susceptibility to Graves disease, an autoimmune disorder associated with overactivity of the thyroid gland and hyperthyroidism. Ref.27Diabetes mellitus, insulin-dependent, 12 (IDDM12) [MIM:601388]: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.24 Ref.27Celiac disease 3 (CELIAC3) [MIM:609755]: A multifactorial, chronic disorder of the small intestine caused by intolerance to gluten. It is characterized by immune-mediated enteropathy associated with failed intestinal absorption, and malnutrition. In predisposed individuals, the ingestion of gluten-containing food such as wheat and rye induces a flat jejunal mucosa with infiltration of lymphocytes.Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.25 Ref.27 Ref.31. Pharmaceutical use: Engineered fusion proteins consisting of the extracellular domain of CTLA4 and the IgG Fc region (Ctla4-Ig), inhibit T-cell-dependent antibody responses, and are used as immunosuppressive agents. They are soluble, have an enhanced affinity for B7 ligands and act as a competitive inhibitor of CD28. Sequence similarities: Contains 1 Ig-like V-type (immunoglobulin-like) domain.
尺寸1 :
0.25毫克
价格1 :
340美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。