抗体

抗小鼠CD19抗原单克隆抗体

MBS520486

0.05毫克

225美元

单克隆

大鼠

PE

6D5

人类, 小鼠

抗体

抗小鼠CD19抗原单克隆抗体

CD19

CD19, PE(克隆6D5)(大鼠IgG2a);PE抗小鼠CD19单克隆抗体

CD19; B-lymphocyte antigen CD19; B-lymphocyte antigen CD19; differentiation antigen CD19; T-cell surface antigen Leu-12; B-lymphocyte surface antigen B4; CD19 molecule; B-lymphocyte surface antigen B4; Differentiation antigen CD19; T-cell surface antigen Leu-12

CD19

CD19;CD19;B4;CVID3

CD19_HUMAN

单克隆

大鼠IgG2a

6D5

大鼠

小鼠

556

小鼠CD19

PE

Antibody Concentration: 0.1 mg/ml

For all formats, store at 4 degree C. DO NOT FREEZE PE conjugates. For long term storage (Purified, FITC) aliquot and freeze unused portion at -20 Degree C in volumes appropriate for single usage. Avoid freeze/thaw cycles.

Presentation: FITC/PE conjugated IgG buffered in PBS, 0.02% NaN3 and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/ml.

anti-mouse CD19 antigen monoclonal antibody is a pan B cell marker. It will not detect plasma cells. This antibody is suitable for use in flow cytometry.

901823

AAA69966.1

P15391

61,128 Da

Adaptive Immune System Pathway (366160); Antigen Activates B Cell Receptor Leading To Generation Of Second Messengers Pathway (576249); B Cell Receptor Signaling Pathway (198909); B Cell Receptor Signaling Pathway (83081); B Cell Receptor Signaling Pathway (492); BCR Signaling Pathway (138058); Constitutive PI3K/AKT Signaling In Cancer Pathway (685535); DAP12 Interactions Pathway (685549); DAP12 Signaling Pathway (685550); Disease Pathway (530764)

Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008]

Function: Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. Subunit structure: Forms a complex with CD21, CD81 and CD225 in the membrane of mature B-cells. Interacts with VAV. Interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. Interacts with PLCG2 when phosphorylated on Tyr-409. Interacts with LYN. Ref.11 Ref.13. Subcellular location: Membrane; Single-pass type I membrane protein. Post-translational modification: Phosphorylated on serine and threonine upon DNA damage, probably by ATM or ATR. Phosphorylated on tyrosine following B-cell activation. Phosphorylated on tyrosine residues by LYN. Ref.11 Ref.12 Ref.13. Involvement in disease: Immunodeficiency, common variable, 3 (CVID3) [MIM:613493]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.14. Sequence similarities: Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Sequence caution: The sequence AAA35533.1 differs from that shown. Reason: Frameshift at position 396.

0.05毫克

225美元

0.3毫克

470