抗体

桥粒芯蛋白1抗体

MBS530355

5毫升

395美元

单克隆

小鼠

未共轭

Dsg1-P23

免疫印迹, 免疫组化, 免疫组化-石蜡切片

抗体

桥粒芯蛋白1抗体

桥粒芯蛋白1

单克隆桥粒芯蛋白1;抗桥粒芯蛋白1

desmoglein-1 preproprotein; Desmoglein-1; desmoglein-1; desmoglein 1; Cadherin family member 4; Desmosomal glycoprotein 1; DG1; DGI; Pemphigus foliaceus antigen

DSG1;DSG1;DG1;DSG;CDHF4;EPKHE;PPKS1;SPPK1;EPKHIA;CDHF4;DG1;DGI

DSG1_HUMAN

单克隆

IgG1

Dsg1-P23

小鼠

人类桥粒芯蛋白1

1049

Culture supernatant

Hybridoma culture supernatant with 0.09% NaN3

5.0ml per vial

Store at 4 degree C.

免疫组化(免疫组化)福尔马林/石蜡, 免疫印迹(免疫印迹)

Biological Significance: The desmogleins are a family of cadherins consisting of proteins DSG1, DSG2, DSG3, and DSG4. They play a role in the formation of desmosomes that join cells to one another. Desmoglein 1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells.

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product. Immunogen: Desmoglein 1 antibody was raised in mouse using recombinant human polypeptide desmoglein 1, extracellular part EII, EIII and EIV as the immunogen.

细胞生物学

小鼠单克隆桥粒芯蛋白1抗体

119703744

NP_001933.2

NM_001942.2

Q02413

42,619 Da

Apoptosis Pathway (105648); Apoptotic Cleavage Of Cell Adhesion Proteins Pathway (105680); Apoptotic Cleavage Of Cellular Proteins Pathway (105678); Apoptotic Execution Phase Pathway (105677); Programmed Cell Death Pathway (1127510); Staphylococcus Aureus Infection Pathway (172846); Staphylococcus Aureus Infection Pathway (171867)

This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma. [provided by RefSeq, Feb 2015]

DSG1: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Defects in DSG1 are the cause of palmoplantar keratoderma striate type 1 (SPPK1); also known as keratosis palmoplantaris striata I. SPPK1 is a dermatoligical disorder characterized by thickening of the skin on the palms and soles, and longitudinal hyperkeratotic lesions on the palms, running the length of each finger. Protein type: Cell adhesion; Membrane protein, integral. Chromosomal Location of Human Ortholog: 18q12.1. Cellular Component: desmosome; internal side of plasma membrane; apical plasma membrane; plasma membrane; integral to membrane; intercellular junction; cytosol; lateral plasma membrane. Molecular Function: toxin binding; gamma-catenin binding; calcium ion binding. Biological Process: intercellular junction assembly; cell-cell adhesion; maternal process involved in pregnancy; protein stabilization; apoptosis; calcium-dependent cell-cell adhesion; response to progesterone stimulus; homophilic cell adhesion; cell structure disassembly during apoptosis. Disease: Palmoplantar Keratoderma I, Striate, Focal, Or Diffuse; Erythroderma, Congenital, With Palmoplantar Keratoderma, Hypotrichosis, And Hyper-ige

5毫升

395美元