抗体

HGF抗体

MBS530424

0.5毫克

1445美元

单克隆

小鼠

未共轭

M952901

免疫印迹, 中和反应

抗体

HGF抗体

HGF

Monoclonal HGF; Anti-HGF; Scatter Factor; Hepatocyte Growth Factor; HPTA; SF; Hepatopoietin

hepatocyte growth factor; Hepatocyte growth factor; hepatocyte growth factor; hepatocyte growth factor (hepapoietin A; scatter factor); Hepatopoietin-A; Scatter factor; SF

HGF

HGF;HGF;SF;HGFB;HPTA;F-TCF;DFNB39;HPTA;SF

HGF_HUMAN

单克隆

IgG1

M952901

小鼠

人类HGF

723

以冻干粉末状提供

Store at -20 degree C until reconstitution. Following reconstitution product may be stored at 4 degree C in the short term. For long term storage aliquot and freeze at -20 degree C. Avoid repeated freeze/thaw cycles.

中和反应, 免疫印迹(免疫印迹)

Neutralization: 0.1-0.3 ug/ml. WB: 1 ug/ml

Biological Significance: HGF, also known as scatter factor and hepatopoietin A, is a pleiotropic protein in the plasminogen subfamily of S1 peptidases. It is a multidomain molecule that includes an Nterminal PAN/APPLE like domain, four Kringle domains, and a serine proteinaselike domain that has no detectable protease activity (1 5). Human HGF is secreted as an inactive 728 amino acid (aa) single chain propeptide. Endotoxin Levels: <0.1 EU per 1 ug of the antibody by the LAL method.

Immunogen: HGF antibody was raised in mouse using S. frugiperda insect ovarian cell line Sf 21-derived recombinant human HGF as the immunogen.

细胞因子&生长因子

小鼠单克隆HGF抗体

337938

AAA64297.1

P14210

24,116 Da

Arf6 Signaling Events Pathway (138034); Cytokine Signaling In Immune System Pathway (366171); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Direct P53 Effectors Pathway (137939); FGF Signaling Pathway (137989); Focal Adhesion Pathway (198795); Focal Adhesion Pathway (83067); Focal Adhesion Pathway (478); Hemostasis Pathway (106028)

Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

HGF: HGF is a potent mitogen for mature parenchymal hepatocyte cells, seems to be an hepatotrophic factor, and acts as growth factor for a broad spectrum of tissues and cell types. It has no detectable protease activity. Activating ligand for the receptor tyrosine kinase MET by binding and promoting its dimerization. Defects in HGF are the cause of deafness autosomal recessive type 39 (DFNB39). A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Belongs to the peptidase S1 family. Plasminogen subfamily. 6 isoforms of the human protein are produced by alternative splicing. Protein type: Cell development/differentiation; Hormone; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 7q21.1. Cellular Component: extracellular space; membrane; extracellular region. Molecular Function: identical protein binding; protein binding; growth factor activity; protein heterodimerization activity; serine-type endopeptidase activity; chemoattractant activity. Biological Process: positive regulation of myelination; mitosis; platelet activation; organ regeneration; activation of MAPK activity; myoblast proliferation; hepatocyte growth factor receptor signaling pathway; negative regulation of caspase activity; proteolysis; liver development; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of osteoblast differentiation; positive regulation of angiogenesis; positive regulation of peptidyl-tyrosine phosphorylation; platelet degranulation; positive chemotaxis; epithelial to mesenchymal transition; positive regulation of transcription from RNA polymerase II promoter; blood coagulation; hyaluronan metabolic process; positive regulation of cell migration. Disease: Deafness, Autosomal Recessive 39

0.5毫克

1445美元