抗体

IL2Ra抗体

MBS532180

0.5毫克

310美元

单克隆

小鼠

未共轭

M912289

免疫印迹, 酶联免疫吸附测定, 酶免疫法

抗体

IL2Ra抗体

IL2Ra

Monoclonal IL2Ra; Anti-IL2Ra; MCGF; IL 2Ra; IL2Ra; P-cell stimulation factor; IL-2Ra; Multi-CSF; HCGF; Mast cell growth factor; Interleukin 3; IL-3

interleukin-2 receptor subunit alpha isoform 1; Interleukin-2 receptor subunit alpha; interleukin-2 receptor subunit alpha; interleukin 2 receptor, alpha; TAC antigen; p55; CD_antigen: CD25

IL2Ra

IL2RA;IL2RA;p55;CD25;IL2R;TCGFR;IDDM10;IL-2受体亚单位甲;IL-2;IL-2R亚单位甲;白细胞介素-RA

IL2RA_HUMAN

单克隆

IgG2a kappa

M912289

小鼠

人类IL-2受体

272

Sterile filtered lyophilized powder from PBS. Centrifuge the vial prior to opening. Reconstitute in sterile water for a final concentration of 1.0mg/ml

500微克, 冻干

Ships ambient or refrigerated. Upon receipt store at 4 degree C short term: -20 degree C long term. Avoid repeated freeze-thaw cycles.

酶联免疫吸附测定(EIA), 抑制作用, 免疫印迹(免疫印迹)

ELISA: 4-8 ug/ml. Inhibition: 1-1.5 ug/ml

Biological Significance: IL3 is a hematopoietic growth factor that promotes the survival, differentiation and proliferation of committed progenitor cells of the megakaryocyte, granulocyte-macrophage, erythroid, eosinophil, basophil and mast cell lineages. Produced by T cells, mast cells and eosinophils, IL3 enhances thrombopoieses, phagocytosis, and antibody-mediated cellular cytotoxicity. Its ability to activate monocytes suggests that IL3 may have additional immunoregulatory roles. Many of the IL3 activities depend upon co-stimulation with other cytokines. IL3 is species-specific, variably glycosylated cytokine.

Immunogen: Hi-5 Insect cells

细胞因子&生长因子

小鼠单克隆IL2Ra抗体

4557667

NP_000408.1

NM_000417.2

P01589

Arf6 Trafficking Events Pathway (137954); Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway (137993); Calcium Signaling In The CD4+ TCR Pathway (137941); Cytokine Signaling In Immune System Pathway (366171); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Downstream Signaling In Naive CD8+ T Cells Pathway (138018); Endocytosis Pathway (102279); Endocytosis Pathway (102181); G Beta:gamma Signalling Through PI3Kgamma Pathway (119540)

The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009]

IL2RA: Receptor for interleukin-2. Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 10p15-p14. Cellular Component: plasma membrane; integral to membrane; external side of plasma membrane. Molecular Function: interleukin-2 receptor activity; drug binding; interleukin-2 binding. Biological Process: Notch signaling pathway; regulation of T cell homeostatic proliferation; apoptosis; negative regulation of immune response; negative regulation of defense response to virus; positive regulation of activated T cell proliferation; cell proliferation; negative regulation of T cell proliferation; cell surface receptor linked signal transduction; inflammatory response to antigenic stimulus; positive regulation of T cell differentiation; negative regulation of inflammatory response; immune response; inflammatory response; activated T cell apoptosis. Disease: Interleukin 2 Receptor, Alpha, Deficiency Of; Diabetes Mellitus, Insulin-dependent, 10

0.5毫克

310美元