抗体

DKK1抗体

MBS533843

0.1毫升

395美元

单克隆

小鼠

未共轭

2H2

免疫印迹, 酶联免疫吸附测定, 酶免疫法

抗体

DKK1抗体

DKK1

Monoclonal DKK1; Anti-DKK1; Dickkopt-1; DKK-1; hdkk-1; DKK 1; hdkk1; Dickkopf-related protein-1; dkk1; DKK1; SK

dickkopf-related protein 1; Dickkopf-related protein 1; dickkopf-related protein 1; dickkopf WNT signaling pathway inhibitor 1; SK

DKK1

DKK1; DKK1; SK; DKK-1; Dickkopf-1; Dkk-1; hDkk-1

DKK1_HUMAN

单克隆

IgG2b

2H2

小鼠

人类

266

Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.

Store at 4 degree C for short term storage. Store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹)

ELISA: 1:10, 000。 WB: 1:500-1:2000

Biological Significance: Dickkopf-related protein 1 is a protein that in humans is encoded by the DKK1 gene. This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway.

Immunogen: DKK1 antibody was raised in Mouse using a purified recombinant fragment of DKK1 expressed in E Coli as the immunogen.

Differentiation & Development

小鼠单克隆DKK1抗体

7110719

NP_036374.1

NM_012242.2

O94907

28,672 Da

Cardiac Progenitor Differentiation Pathway (712094); Direct P53 Effectors Pathway (137939); Disease Pathway (530764); Diseases Of Signal Transduction Pathway (1183518); Presenilin Action In Notch And Wnt Signaling Pathway (137914); Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway (169352); Signal Transduction Pathway (477114); Signaling By WNT In Cancer Pathway (1127614); Signaling By Wnt Pathway (106510); TCF Dependent Signaling In Response To WNT Pathway (1127516)

This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. [provided by RefSeq, Jul 2008]

DKK1: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Interacts with LRP6. Interacts (via the C-termianl Cys- rich domain) with LRP5 (via beta-propeller regions 3 and 4); the interaction, enhanced by MESD and or KREMEN, antagonizes Wnt- mediated signaling. Placenta. Belongs to the dickkopf family. Protein type: Secreted, signal peptide; Secreted; Inhibitor. Chromosomal Location of Human Ortholog: 10q11.2. Cellular Component: extracellular space; early endosome membrane; extracellular region; plasma membrane. Molecular Function: signal transducer activity; protein binding; receptor antagonist activity; growth factor activity; low-density lipoprotein receptor binding. Biological Process: cellular morphogenesis during differentiation; negative regulation of skeletal muscle development; response to retinoic acid; negative regulation of Wnt receptor signaling pathway; regulation of receptor internalization; negative regulation of peptidyl-serine phosphorylation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of BMP signaling pathway; mesoderm formation; negative regulation of mesodermal cell fate specification; hair follicle development; endoderm formation; forebrain development; regulation of endodermal cell fate specification; negative regulation of protein complex assembly; embryonic limb morphogenesis

0.1毫升

395美元