抗体

5脂肪氧化酶抗体

MBS534195

0.1毫升

675美元

多克隆

兔

未共轭

人类, 大鼠

抗体

5脂肪氧化酶抗体

5脂肪氧化酶

Polyclonal 5 Lipoxygenase; Anti-5 Lipoxygenase; -Lipoxygenase -5; -Lipoxygenase 5; 5-Lipoxygenase

5-lipoxygenase, partial; Arachidonate 5-lipoxygenase; arachidonate 5-lipoxygenase; arachidonate 5-lipoxygenase

ALOX5;ALOX5;5-LO;5LPG;LOG5;5-LOX;LOG5;5-LO;5脂肪氧化酶

LOX5_HUMAN

多克隆

兔

大鼠

50

人类5脂肪氧化酶

10mM HEPES, pH 7.5, with 150mM NaCl, 100 ug/ml BSA and 50% Glycerol.

Store at 4 degree C for short term storage. Aliquot and store at -80 degree C for long term storage. Avoid repeated freeze/thaw cycles.

免疫印迹(免疫印迹)

Biological Significance: 5-lipoxygenase (5-LO) catalyzes the formation of 5(S)-HpETE from arachidonic acid and its subsequent conversion to leukotriene A4. It is localized in the cytosol of resting human and rat peripheral blood neutrophils, whereas it is found in the nucleus in rat basophilic leukemia cells and human alveolar macrophages. Upon stimulation of the cell, 5-LO translocates to the nuclear membrane where it is found in association with 5-LO activating protein (FLAP) and with the 85 kDa cPLA2.

Immunogen: 5 Lipoxygenase antibody was raised in rabbit using phosphopeptide corresponding to amino acid residues surrounding the phosphoserine 523 of human 5-lipoxygenase (5-LO) as the immunogen.

Proteases, Inhibitors, Purified Polyclonal Antibodies

亲和纯化兔多克隆5脂肪氧化酶抗体

187167

AAA63212.1

P09917

56,291 Da

Arachidonic Acid Metabolism Pathway 82991!!Arachidonic Acid Metabolism Pathway 685553!!Arachidonic Acid Metabolism Pathway 366!!Eicosanoid Synthesis Pathway 198888!!IL-5 Signaling Pathway 198770!!Metabolic Pathways 132956!!Metabolism Pathway 477135!!Metabolism Of Lipids And Lipoproteins Pathway 160976!!Ovarian Steroidogenesis Pathway 790011!!Ovarian Steroidogenesis Pathway 795173

This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

0.1毫升

675美元