抗体

白细胞介素-13抗体

MBS534461

0.1毫克

370美元

多克隆

兔

nonconjugated

免疫印迹, 酶联免疫吸附测定, 酶免疫法

抗体

白细胞介素-13抗体

白细胞介素-13

多克隆白细胞介素-13;抗白细胞介素-13;IL-13;NC300;白细胞介素-13;白细胞介素13;白细胞介素13;人类P600

白细胞介素13;白细胞介素13;白细胞介素13;白细胞介素13

白细胞介素-13

白细胞介素-13;白细胞介素-13;P600;IL-13;NC30;IL-13

IL13_HUMAN

多克隆

兔

To be determined by end-user

146

人类IL-13

冻干来自0.5x PBS, pH值7.4

Store at -20 degree C until reconstitution. Following reconstitution product may be stored at 4 degree C in the short term. For long term storage aliquot and freeze at -20 degree C. Avoid repeated freeze/thaw cycles.

酶联免疫吸附测定(EIA), 抑制作用, 免疫印迹(免疫印迹)

ELISA: 0.5-2 ug/ml. Inhibition: 0.12-0.15 ug/ml. WB: 0.1-0.2 ug/ml

Biological Significance: IL13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL13 in mice resulted in impaired Th2 cell development and indicated an important role for IL13 in the expulsion of gastrointestinal parasites. IL13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL1beta, TNF-alpha, IL6 and IL8. IL13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Blocking of IL13 activity inhibits the pathophysiology of asthma. Human and Mouse IL13 is cross-species reactive.

Immunogen: IL13 antibody was raised in rabbit using highly pure recombinant human IL-13 as the immunogen.

细胞因子&生长因子;纯化多克隆抗体

亲和纯化兔多克隆白细胞介素-13抗体

26787978

NP_002179.2

NM_002188.2

P35225

12.3 kDa (predicted detection band MW)

Asthma Pathway 83120!!Asthma Pathway 532!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Cytokines And Inflammatory Response Pathway 198794!!Fc Epsilon RI Signaling Pathway 83082!!Fc Epsilon RI Signaling Pathway 493!!Glucocorticoid Receptor Regulatory Network Pathway 138014!!IL12 Signaling Mediated By STAT4 Pathway 137936!!Inflammatory Bowel Disease (IBD) Pathway 842771

This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]

0.1毫克

370美元