抗体

GM-CSF抗体

MBS535397

0.05毫克

330美元

多克隆

兔

未共轭

免疫印迹, 酶联免疫吸附测定, 酶免疫法

抗体

GM-CSF抗体

GM-CSF

Polyclonal GM-CSF; Anti-GM-CSF; CSF-2; Granulocyte/Macrophage Colony-Stimulating Factor; pluripoietin-alpha; MGI-1GM; GM-CSF

granulocyte-macrophage colony-stimulating factor; Granulocyte-macrophage colony-stimulating factor; granulocyte-macrophage colony-stimulating factor; colony stimulating factor 2 (granulocyte-macrophage); Colony-stimulating factor; CSF; Molgramostin; Sargramostim

GM-CSF

CSF2;CSF2;GMCSF;GMCSF;GM-CSF;CSF

CSF2_HUMAN

多克隆

兔

人类GM-CSF

144

Lyophilized from PBS, pH 7.2. Reconstitute in sterile water at a concentration of >0.2 mg/ml.

50ug per vial, lyophilized.

Store at -20 degree C until reconstitution. Following reconstitution product may be stored at 4 degree C in the short term. For long term storage aliquot and freeze at -20 degree C. Avoid repeated freeze/thaw cycles.

酶联免疫吸附测定(EIA), 抑制作用, 免疫印迹(免疫印迹)

ELISA: 0.5-2 ug/ml. Inhibition: 0.13-0.2 ug/ml. WB: 0.1-0.2 ug/ml

Biological Significance: GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in by endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and Mouse molecules are species-specific and exhibit no cross-species reactivity.

Immunogen: GM-CSF antibody was raised in rabbit using highly pure recombinant human GM-CSF as the immunogen.

免疫学;纯化多克隆抗体

亲和纯化兔多克隆GM-CSF抗体

27437030

NP_000749.2

NM_000758.3

P04141

14.5 kDa (predicted detection band MW)

Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway (137993); Calcium Signaling In The CD4+ TCR Pathway (137941); Cytokine Signaling In Immune System Pathway (366171); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Cytokines And Inflammatory Response Pathway (198794); Fc Epsilon RI Signaling Pathway (83082); Fc Epsilon RI Signaling Pathway (493)

The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008]

GMCSF: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. Belongs to the GM-CSF family. Protein type: Secreted; Secreted, signal peptide; Cytokine. Chromosomal Location of Human Ortholog: 5q31.1. Cellular Component: extracellular space; extracellular region. Molecular Function: protein binding; growth factor activity; granulocyte macrophage colony-stimulating factor receptor binding; cytokine activity. Biological Process: negative regulation of cytolysis; epithelial fluid transport; embryonic placenta development; macrophage activation; positive regulation of tyrosine phosphorylation of Stat5 protein; positive regulation of interleukin-23 production; positive regulation of cell proliferation; immune response; myeloid dendritic cell differentiation; positive regulation of DNA replication

0.05毫克

330美元