产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
IL1RA抗体
目录 :
MBS535760
规格 :
0.05毫克
价格 :
310美元
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定, 酶免疫法
更多信息或购买 :
产品信息
目录号 :
MBS535760
产品类型 :
抗体
产品全称 :
IL1RA抗体
产品简称 :
IL1RA
产品名称同义词 :
多克隆IL1RA;抗IL1RA;ICIL-1RA;ILRA 1;IL-1Ra;IL-1R甲;IL1RA;白细胞介素1R甲;ILRA-1;IL-1RN;IRAP
其他名称 :
interleukin-1 receptor antagonist protein isoform 4; Interleukin-1 receptor antagonist protein; interleukin-1 receptor antagonist protein; interleukin 1 receptor antagonist; ICIL-1RA; IL1 inhibitor; INN: Anakinra
产品基因名称 :
IL1RA
其他基因名称 :
IL1RN;IL1RN;DIRA;IRAP;IL1F3;IL1RA;MVCD4;IL-1RN;IL-1ra;IL-1ra3;ICIL-1RA;IL1F3;IL1RA;IL-1RN;IL-1ra;IRAP
UniProt数据库进入名 :
IL1RA_HUMAN
克隆性 :
多克隆
宿主 :
兔
反应物种 :
未确定
序列长度 :
143
形式 :
Sterile filtered lyophilized powder from PBS, pH 7.2. Centrifuge the vial prior to opening. Reconstitute in sterile water to a final concentration of 0.1-1.0mg/ml.
浓度 :
50微克, 冻干
储存稳定性 :
Store at -20 degree C until reconstitution. Following reconstitution product may be stored at 4 degree C in the short term. For long term storage aliquot and freeze at -20 degree C. Avoid repeated freeze/thaw cycles.
检测过的应用 :
酶联免疫吸附测定(EIA), 抑制作用, 免疫印迹(免疫印迹)
应用笔记 :
ELISA: 0.5-2 ug/ml. Inhibition: 2.5-3.7 ug/ml. WB: 0.1-0.2 ug/ml
其它信息1 :
Biological Significance: Interleukin-1 receptor antagonist (IL1RA) is a naturally occurring inflammatory inhibitor protein. It inhibits the activity of IL1a and IL1beta by competitively blocking binding to their type I and type II receptors. IL1Ra is produced by corneal epithelial cells, monocytes, neutrophils, macrophages, and fibroblasts. Therapeutically, IL1Ra may help in the treatment of sepsis, cachexia, rheumatoid arthritis, chronic myelogenous leukemia, asthma, psoriasis, and inflammatory bowel disease.
其他信息2 :
Immunogen: E.coli derived recombinant Human IL-1RA
产品种类 :
细胞因子&生长因子;纯化多克隆抗体
产品描述 :
亲和纯化兔多克隆IL1RA抗体
NCBI GI登录号 :
27894321
NCBI登录号 :
NP_776215.1
NCBI基因登录号 :
NM_173843.2
UniProt数据库登录号 :
P18510
NCBI分子量 :
17.2 kDa (predicted detection band MW)
NCBI信号通路 :
Cytokine Signaling In Immune System Pathway (366171); IL-1 Signaling Pathway (198908); IL1-mediated Signaling Events Pathway (137944); Immune System Pathway (106386); Interleukin-1 Signaling Pathway (160141); Leptin Signaling Pathway (672456); SIDS Susceptibility Pathways (198901); Signaling By Interleukins Pathway (160140)
NCBI总结 :
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
IL1RN: Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure. The intracellular form of IL1RN is predominantly expressed in epithelial cells. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Vesicle; Secreted, signal peptide; Secreted; Cytokine. Chromosomal Location of Human Ortholog: 2q14.2. Cellular Component: extracellular space; cytoplasm; plasma membrane; intracellular. Molecular Function: interleukin-1 Type I receptor antagonist activity; interleukin-1 receptor binding; interleukin-1 Type II receptor antagonist activity; interleukin-1, Type II receptor binding; cytokine activity; interleukin-1, Type I receptor binding; interleukin-1 receptor antagonist activity. Biological Process: response to drug; positive regulation of JNK activity; negative regulation of heterotypic cell-cell adhesion; negative regulation of glutamate secretion; response to glucocorticoid stimulus; carboxylic acid metabolic process; response to lipopolysaccharide; female pregnancy; fever; sensory perception of pain; chronic inflammatory response to antigenic stimulus; memory; response to starvation; insulin secretion; acute-phase response; negative regulation of cytokine and chemokine mediated signaling pathway; immune response; lipid metabolic process; response to activity; negative regulation of membrane potential; negative regulation of cell migration; negative regulation of apoptosis. Disease: Gastric Cancer, Hereditary Diffuse; Microvascular Complications Of Diabetes, Susceptibility To, 4; Osteomyelitis, Sterile Multifocal, With Periostitis And Pustulosis
尺寸1 :
0.05毫克
价格1 :
310美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。