蛋白

VEGFR2蛋白(Fc嵌合体)

MBS536571

0.01毫克

255美元

重组蛋白

VEGFR2蛋白(Fc嵌合体)

VEGFR2

VEGFR-2蛋白;sKDR D1-7蛋白;蛋白酪氨酸激酶受体FLK1蛋白;CD309蛋白;类型III受体酪氨酸激酶蛋白;D1-7 proteinKDR D1-7蛋白;FLK1蛋白;激酶插入区受体蛋白;激酶插入域受体蛋白;VEGFR2-Fc嵌合体

vascular endothelial growth factor receptor 2; Vascular endothelial growth factor receptor 2; vascular endothelial growth factor receptor 2; kinase insert domain receptor; Fetal liver kinase 1; FLK-1; Kinase insert domain receptor; KDR; Protein-tyrosine kinase receptor flk-1; CD_antigen: CD309

VEGFR2

激酶插入区受体;激酶插入区受体;FLK1;CD309;VEGFR;VEGFR2;FLK1;VEGFR2;VEGFR-2;FLK-1;激酶插入区受体

VGFR2_HUMAN

人类

1356

> 90% pure. VEGFR2 protein (Fc Chimera) was purified by a proprietary chromatographic technique.

Lyophilized from a solution of 1x PBS, pH 7.4.

Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze-thaw cycles.

User optimized

Protein Type: Recombinant. Biological Significance: Endothelial cells express three different vascular endothelial growth factor (VEGF) receptors, belonging to the family of receptor tyrosine kinases (RTKs). They are named VEGFR-1 (Flt-1), VEGFR-2 (kDaR/Flk-1), VEGFR-3 (Flt-4). Their expression is almost exclusively restricted to endothelial cells, but VEGFR-1 can also be found on monocytes. All VEGF-receptors have seven immunoglobulin-like extracellular domains, a single transmembrane region and an intracellular split tyrosine kinase domain. VEGFR-2 has a lower affinity for VEGF than the Flt-1 receptor, but a higher signaling activity. Mitogenic activity in endothelial cells is mainly mediated by VEGFR-2 leading to their proliferation.Differential splicing of the flt-1 gene leads to the formation of a secreted, soluble variant of VEGFR-1 (sVEGFR-1). Bioactivity: The activity of sVEGFR-2/Fc was determined by its ability to inhibit the VEGF-dependent proliferation of human umbilical vein endothelial cells. The ED50 for this effect is typically 10-30 ng/ml.

Expression System: Baculovirus. Tag/Conjugate: Fc chimera

细胞因子&生长因子

纯化重组人类VEGFR2蛋白(Fc嵌合体)

11321597

NP_002244.1

NM_002253.2

P35968

160 kDa

Angiogenesis Pathway 198772!!Axon Guidance Pathway 105688!!Cardiac Progenitor Differentiation Pathway 712094!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Developmental Biology Pathway 477129!!EPH-Ephrin Signaling Pathway 1127691!!EPHA-mediated Growth Cone Collapse Pathway 1127692!!Endocytosis Pathway 102279!!Endocytosis Pathway 102181

Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]

0.01毫克

255美元