抗体

Toll样受体5抗体

MBS540533

0.1 mg Affinity-Puri

390美元

多克隆

兔

未共轭

人类, 小鼠

免疫印迹, 酶联免疫吸附测定, 免疫沉淀, 酶免疫法

抗体

Toll样受体5抗体

Toll样受体5

SLEB1; TIL3; Toll like receptor 5; Toll/interleukin 1 receptor like protein 3 antibody

Toll-like receptor 5; Toll-like receptor 5; toll-like receptor 5; toll like receptor 5; Toll/interleukin-1 receptor-like protein 3

Toll样受体5

Toll样受体5;Toll样受体5;SLE1;TIL3;SLEB1;MELIOS;TIL3

TLR5_HUMAN

多克隆

兔

猫, 人类, 小鼠, 猪

858

亲和纯化

0.75 ug/ul in antibody stabilization buffer

-20 degree C for long term storage

酶联免疫吸附测定(EIA), 免疫沉淀(免疫沉淀), 免疫印迹(免疫印迹)

Dot Blot: 1:20,000. ELISA: 1:20,000. Immunoprecipitation: 1:200. Western Blot: 1:500

Immunogen: Synthetic peptide taken within amino acid region 195-225 on human TLR5 protein. Expression: Highly expressed in ovary and in peripheral blood leukocytes, especially in monocytes, less in CD11c+ immature dendritic cells. Also detected in prostate and testis.

Molecular Function: Receptor, interleukin-1 receptor binding, transmembrane signalling receptor activity. Structure: Binds MYD88 via their respective TIR domains (By similarity). Homodimer both in the absence and presence of ligand. Subcellular Location: Membrane; Single-pass type I membrane protein

Primary Antibodies; Immunology; Innate Immunity; Macrophage / Inflammation; TLR5 Antibody

Affinity Purified Toll-like receptor 5 Antibody. Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

215274239

O60602.4

O60602

97,834 Da

Disease Pathway (1268854); Diseases Associated With The TLR Signaling Cascade Pathway (1269157); Diseases Of Immune System Pathway (1269156); IRAK4 Deficiency (TLR5) Pathway (1269159); Immune System Pathway (1269170); Inflammatory Bowel Disease (IBD) Pathway (842771); Inflammatory Bowel Disease (IBD) Pathway (842797); Innate Immune System Pathway (1269203); Legionellosis Pathway (469200); Legionellosis Pathway (469186)

This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009]

TLR5: Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Genetic variation in TLR5 is associated with resistance to systemic lupus erythematosus type 1 (SLEB1). Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Belongs to the Toll-like receptor family. Protein type: Receptor, misc.; Membrane protein, integral. Chromosomal Location of Human Ortholog: 1q41-q42. Cellular Component: integral to plasma membrane; plasma membrane. Molecular Function: interleukin-1 receptor binding; receptor activity; transmembrane receptor activity. Biological Process: defense response to Gram-negative bacterium; inflammatory response; innate immune response; male gonad development; MyD88-dependent toll-like receptor signaling pathway; positive regulation of interleukin-8 production; positive regulation of nitric oxide biosynthetic process; positive regulation of toll-like receptor signaling pathway; regulation of cytokine secretion; toll-like receptor 5 signaling pathway. Disease: Legionnaire Disease, Susceptibility To; Melioidosis, Susceptibility To; Systemic Lupus Erythematosus, Susceptibility To, 1

0.1毫克亲和纯化

390美元