抗体

CD10抗体

MBS540557

0.1 mg Affinity-Puri

390美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠

免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 酶免疫法

抗体

CD10抗体

CD10

Atriopeptidase; CALLA; CD10; Common acute lymphocytic leukemia antigen; DKFZp686O16152; EC 3.4.24.11; Enkephalinase; EPN; gp100; Membrane metallo endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10); Membrane metallo endopeptidase; MGC126681; MGC126707; MME; NEP; Neprilysin; Neutral endopeptidase; SFE; Skin fibroblast elastase antibody

neprilysin; Neprilysin; neprilysin; membrane metallo-endopeptidase; Atriopeptidase; Common acute lymphocytic leukemia antigen; CALLA; Enkephalinase; Neutral endopeptidase 24.11; NEP; Neutral endopeptidase; Skin fibroblast elastase; SFE; CD_antigen: CD10

CD10

MME;MME;NEP;SFE;CD10;CALLA;EPN;CALLA;NEP;中性肽链内切酶;SFE

NEP_HUMAN

多克隆

兔

人类, 小鼠, 大鼠

750

亲和纯化

0.72-0.78 ug/ul in antibody stabilization buffer

-20 degree C for long term storage

共聚焦显微镜(CM), 酶联免疫吸附测定(EIA), 免疫细胞化学(免疫细胞化学), 免疫荧光(IF), 免疫组化(免疫组化), 免疫沉淀(免疫沉淀), 免疫印迹(免疫印迹)

ELISA: 1:10,000. Immunocytochemistry: 1:250. Immunofluorescence: 1:250. Immunohistochemistry: 1:250. Immunoprecipitation: 1:250. Western Blot: 1:500

Immunogen: Synthetic peptide taken within amino acid region 100-150 on human Neprilysin protein. Immunoglobulin: IgG. Expression: Adipose tissue; duodenum; kidney; small intestine

Determinant: Extreme N-epitope. Molecular Function: Hydrolase, Metalloprotease, Protease. Structure: Belongs to the peptidase M13 family. Subcellular Location: Cell membrane, Membrane

Primary Antibodies; Cancer Research; CD Markers; CD10 Antibody

Affinity Purified Neprilysin Antibody Extreme N-epitope. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. angiotensin maturation; cellular response to UV; replicative senescence

116256327

NP_009218

NM_007287.2

P08473

85,514 Da

Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); Metabolism Of Angiotensinogen To Angiotensins Pathway (1268749); Metabolism Of Proteins Pathway (1268677); Peptide Hormone Metabolism Pathway (1268746); Protein Digestion And Absorption Pathway (172847); Protein Digestion And Absorption Pathway (171868)

This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq, Jul 2008]

CD10: Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV- inducible elastase activity toward skin preelastic and elastic fibers. Inhibited in a dose dependent manner by opiorphin. Belongs to the peptidase M13 family. Protein type: EC 3.4.24.11; Protease; Membrane protein, integral. Chromosomal Location of Human Ortholog: 3q25.2. Cellular Component: axon; brush border; cytoplasm; dendrite; focal adhesion; integral to membrane; integral to plasma membrane; plasma membrane; synapse; synaptic vesicle. Molecular Function: endopeptidase activity; exopeptidase activity; metalloendopeptidase activity; metallopeptidase activity; peptide binding; protein binding; zinc ion binding. Biological Process: angiotensin maturation; beta-amyloid metabolic process; creatinine metabolic process; kidney development; peptide metabolic process; proteolysis; sensory perception of pain. Disease: Membranous Nephropathy, Susceptibility To

0.1毫克亲和纯化

390美元