抗体

整合素乙3抗体

MBS541911

0.1毫克

390美元

多克隆

兔

未共轭

免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫沉淀, 酶免疫法

抗体

整合素乙3抗体

[整合素乙3]

[BDPLT16;BDPLT2;CD61;GP3A;GT;HPA 1;HPA 4;整合素乙3(血小板糖蛋白Ⅲa抗原CD61);整合素β链乙3;ITGB 3;NAIT;血小板纤维蛋白原受体, 乙亚单位;血小板糖蛋白Ⅲa;血小板膜糖蛋白IIIa;PTP抗体]

[integrin beta 3 subunit, partial; Integrin beta-3; integrin beta-3; integrin subunit beta 3; Platelet membrane glycoprotein IIIa; GPIIIa; CD_antigen: CD61]

[ITGB3;ITGB3;GT;CD61;GP3A;BDPLT2;糖蛋白Ⅲa;BDPLT16;GP3A;糖蛋白Ⅲa]

ITB3_HUMAN

多克隆

兔

Human, Monkey

83

亲和纯化免疫球蛋白

0.68 mg/mL in antibody stabilization buffer

存放在-20°C为长期储存

酶联免疫吸附测定(EIA), 免疫组化(免疫组化), 免疫沉淀(免疫沉淀), 免疫印迹(免疫印迹)

Dot Blot: 1:10,000. ELISA: 1:10,000. Immunohistochemistry: 1:100. Immunoprecipitation: 1:150. Western Blot: 1:500

免疫组化(免疫组化)

Immunogen: Synthetic peptide taken within amino acid region 1-50 on human Integrin Beta 3 subunit protein. Expression: Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis. Volume: 200 uL

Molecular Function: Cell adhesion, Host-virus interaction. Structure: Heterodimer of an alpha and a beta subunit. Beta-3 (ITGB3) associates with either alpha-IIb (ITGA2B) or alpha-V (ITGAV). Isoform Beta-3C interacts with FLNB. Interacts with COMP. Interacts with PDIA6 following platelet stimulation. Interacts with SYK; upon activation by ITGB3 promotes platelet adhesion. Interacts with MYO10. Interacts with DAB3. Interacts with FERMT2. Interacts with EMP2; regulates the levels of the heterodimer ITGA5:ITGB3 integrin expression on the plasma membrane (PubMed:16216233). Integrin ITGAV:ITGB3 interacts with FBLN5 (via N-terminus). Integrin ITGAV:ITGB3 interacts with herpes virus 8/HHV-8 glycoprotein B and acts as a receptor for the virus. Interacts with HIV-1 Tat. Subcellular Location: Cell junction, Cell membrane, Cell projection, Membrane

一抗;信号转导;细胞骨架/ECM;整合素;整合素乙3抗体

Affinity Purified Integrin beta chain Beta 3 antibody. Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

5705909

AAB23689.2

P05106

The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008]

ITGB3: integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIB/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIB/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIB/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIB/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Protein type: Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral. Chromosomal Location of Human Ortholog: 17q21.32. Cellular Component: cell surface; filopodium membrane; focal adhesion; integral to plasma membrane; integrin complex; melanosome; microvillus membrane; nucleus; plasma membrane; platelet alpha granule membrane; receptor complex. Molecular Function: C-X3-C chemokine binding; cell adhesion molecule binding; coreceptor activity; enzyme binding; extracellular matrix binding; fibronectin binding; identical protein binding; platelet-derived growth factor receptor binding; protease binding; protein binding; protein disulfide isomerase activity; vascular endothelial growth factor receptor 2 binding; viral receptor activity. Biological Process: activation of protein kinase activity; angiogenesis involved in wound healing; blood coagulation; cell adhesion; cell growth; cell migration; cell-matrix adhesion; cell-substrate adhesion; cell-substrate junction assembly; entry of virus into host cell; extracellular matrix organization and biogenesis; heterotypic cell-cell adhesion; integrin-mediated signaling pathway; leukocyte migration; mesodermal cell differentiation; negative chemotaxis; negative regulation of lipid transport; negative regulation of lipoprotein metabolic process; negative regulation of low-density lipoprotein receptor biosynthetic process; platelet activation; platelet degranulation; positive regulation of endothelial cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein amino acid phosphorylation; positive regulation of vascular endothelial growth factor receptor signaling pathway; protein folding; regulation of bone resorption; smooth muscle cell migration; tube development; vascular endothelial growth factor receptor signaling pathway; wound healing. Disease: Bleeding Disorder, Platelet-type, 16; Glanzmann Thrombasthenia; Myocardial Infarction, Susceptibility To

0.1毫克

390美元