产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
兔抗小鼠CD32b(FCGR2B)多克隆
目录 :
MBS551009
规格 :
0.1毫克
价格 :
280美元
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
未共轭
反应物种 :
人类, 小鼠
应用 :
酶联免疫吸附测定, 酶免疫法
更多信息或购买 :
产品信息
目录号 :
MBS551009
产品类型 :
抗体
产品全称 :
兔抗小鼠CD32b(FCGR2B)多克隆
产品简称 :
小鼠CD32b(FCGR2B)
产品名称同义词 :
兔抗小鼠CD32b(FCGR2B)多克隆纯化;fcgr2b;cd32b;Coding sequence蛋白质编码序列32bpolyclonal;多克隆抗体
其他名称 :
low affinity immunoglobulin gamma Fc region receptor II-b isoform 2; Low affinity immunoglobulin gamma Fc region receptor II-b; CDw32; Fc-gamma RII-b
产品基因名称 :
CD32
其他基因名称 :
FCGR2B;CD32;FCG2;IGFR2;IgG Fc受体II-b;Fc丙;FcRII-b
UniProt数据库进入名 :
FCG2B_HUMAN
克隆性 :
多克隆
抗体亚型 :
IgG
宿主 :
兔
反应物种 :
小鼠
序列长度 :
290
纯度 :
Serum IgG fraction was purified by Protein A affinity chromatography. Purity: >95%
形式 :
0.2 um filtered solution in PBS with 5% trehalose.
储存稳定性 :
The lyophilized antibody is stable for at least 1 year from date of receipt at -20 degree C. Upon reconstitution, this antibody can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months without detectable loss of activity. Avoid repeated freeze/thaw cycles. Shelf Life: >12 months
检测过的应用 :
酶联免疫吸附测定(EIA)
应用笔记 :
ELISA: Use at a concentration range of 0.5-1 ug/ml. The detection limit for FCGR2B is approximately 0.3 ng/well.
其它信息1 :
Source Note: Polyclonal CD32B antibody was produced from sera of rabbits immunized with recombinant mouse CD32B extracellular domain. Presentation: Lyophilized from 0.2um filtered solution in PBS pH 7.4 with 5% trehalose. Dilution: A quick spin of the vial followed by reconstitution in 0.01M PBS pH 7.4 or other diluents.
其他信息2 :
Reconstitution: A quick spin of the vial followed by reconstitution in distilled water. This solution can then be diluted into other buffers.
产品种类 :
多克隆
产品描述 :
The inhibitory Fc- receptor IIB (FcRIIB, CD32B), a type I transmembrane receptor with low affinity for monomeric IgG, is a critical regulatory element in B-cell homeostasis. CD32B controls the threshold and the extent of cell activation by counterbalancing the stimulatory activity of a variety of receptors, including the B-cell antigen receptor. Consistent with its regulatory function, CD32B is found on several hematopoietic cell types, which also express activating FcRs, and represents the predominant FcR expressed by the B-cell lineage.
NCBI GI登录号 :
50511932
NCBI登录号 :
NP_001002273.1
NCBI基因登录号 :
NM_001002273.2
UniProt数据库登录号 :
P31994
NCBI分子量 :
34,044 Da
NCBI信号通路 :
Adaptive Immunity Signaling Pathway (366160); B Cell Receptor Signaling Pathway (198909); B Cell Receptor Signaling Pathway (83081); B Cell Receptor Signaling Pathway (492); BCR Signaling Pathway (138058); Fc Gamma R-mediated Phagocytosis Pathway (114228); Fc Gamma R-mediated Phagocytosis Pathway (106590); Fc-epsilon Receptor I Signaling In Mast Cells Pathway (138050); Immune System Pathway (106386); Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway (106413)
NCBI总结 :
The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
UniProt数据库总结 :
FCGR2B iso2: a transmembrane receptor for the Fc region of complexed or aggregated immunoglobulin gamma (IgG). Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down modulation of previous state of cell activation triggered via antigen receptors on B cells, T cells or via another Fc receptor. Three splice-variant isoforms have been observed. Protein type: Cell surface; Oncoprotein; Membrane protein, integral. Chromosomal Location of Human Ortholog: 1q23. Cellular Component: plasma membrane; integral to membrane. Molecular Function: protein binding; IgG binding. Biological Process: regulation of immune response; viral reproduction; immune response; signal transduction. Disease: Systemic Lupus Erythematosus; Malaria, Susceptibility To
尺寸1 :
0.1毫克
价格1 :
280美元
尺寸2 :
0.2毫克
价格2 :
385
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。