抗体

兔抗胰岛素多克隆

MBS551026

0.1毫克

280美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠

免疫印迹, 酶联免疫吸附测定, 免疫组化, 酶免疫法

抗体

兔抗胰岛素多克隆

[胰岛素]

[兔抗人类胰岛素多克隆纯化;胰岛素;多克隆抗体;多克隆]

[insulin preproprotein; Insulin]

[胰岛素]

[INS]

INS_HUMAN

多克隆

IgG

兔

人类, 小鼠, 大鼠

110

>95%. Serum IgG fraction was purified by Protein G affinity chromatography.

Lyophilized from 0.2 um filtered solution in PBS pH 7.4

The lyophilized antibody is stable for at least 1 year from date of receipt at -20°C. Upon reconstitution, this antibody can be stored in working aliquots at 2-8°C for one month, or at -20°C for six months without detectable loss of activity. Avoid repeated freeze/thaw cycles.

酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹), 免疫组化(免疫组化)

ELISA: Use at a concentration range of 1-2 ug/ml. Western Blot: Use at a concentration range of 2-10 ug/ml. Immunohistochemistry: A suitable range of concentrations of this antibody for IHC is 2-10 ug/ml.

免疫组化

Host Note: Polyclonal anti Insulin was produced from sera of rabbits immunized with synthetic protein containing Insulin C-terminal antigenic determinants.

Dilution: A quick spin of the vial followed by reconstitution in 0.01M PBS, pH 7.4 or other diluents.

多克隆

fxr activation reverses Insulin resistance and lipid abnormalities and protects against liver steatosis in zucker (fa/fa) obese rats . J. Lipid Res., Apr 2010; 51: 771 - 784. expression of tau in Insulin -secreting cells and its interaction with the calcium-binding protein secretagogin . J. Endocrinol., Apr 2010; 205: 25 - 36. silencing of three amblyomma americanum (l.) Insulin -like growth factor binding protein-related proteins prevents ticks from feeding to repletion . J. Exp. Biol., Apr 2010; 213: 1153 - 1161. sclerocarya birrea (anacardiaceae) stem-bark extract corrects glycaemia in diabetic rats and acts on -cells by enhancing glucose-stimulated Insulin secretion . J. Endocrinol., Apr 2010; 205: 79 - 86. atorvastatin causes Insulin resistance and increases ambient glycemia in hypercholesterolemic patients . J. Am. Coll. Cardiol., Mar 2010; 55: 1209 - 1216.

4557671

NP_000198.1

NM_000207.2

P01308

ATF-2 Transcription Factor Network Pathway (138006); Adipogenesis Pathway (198832); Aldosterone-regulated Sodium Reabsorption Pathway (130626); Aldosterone-regulated Sodium Reabsorption Pathway (130590); Amyloids Pathway (366238); Arf6 Trafficking Events Pathway (137954); Diabetes Pathways (105902); Downstream Signaling Of Activated FGFR Pathway (160957); FOXA1 Transcription Factor Network Pathway (137979); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911)

After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

Insulin: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. Heterodimer of a B chain and an A chain linked by two disulfide bonds. Belongs to the insulin family. Protein type: Secreted, signal peptide; Secreted; Hormone. Chromosomal Location of Human Ortholog: 11p15.5. Cellular Component: extracellular space; Golgi lumen; endoplasmic reticulum lumen; extracellular region. Molecular Function: identical protein binding; insulin-like growth factor receptor binding; protein binding; protease binding; hormone activity; insulin receptor binding. Biological Process: positive regulation of nitric oxide biosynthetic process; glucose homeostasis; positive regulation of vasodilation; activation of NF-kappaB transcription factor; positive regulation of glucose import; negative regulation of protein oligomerization; regulation of protein localization; cell-cell signaling; negative regulation of gluconeogenesis; acute-phase response; regulation of transmembrane transporter activity; negative regulation of NAD(P)H oxidase activity; positive regulation of mitosis; positive regulation of nitric-oxide synthase activity; activation of protein kinase B; negative regulation of acute inflammatory response; glucose metabolic process; positive regulation of lipid biosynthetic process; positive regulation of protein amino acid autophosphorylation; positive regulation of cell growth; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of cell differentiation; regulation of amino acid metabolic process; negative regulation of protein catabolic process; negative regulation of glycogen catabolic process; wound healing; positive regulation of glycogen biosynthetic process; positive regulation of cellular protein metabolic process; glucose transport; regulation of protein secretion; negative regulation of vasodilation; regulation of transcription, DNA-dependent; negative regulation of lipid catabolic process; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; negative regulation of proteolysis; negative regulation of protein secretion; MAPKKK cascade; negative regulation of fatty acid metabolic process; alpha-beta T cell activation; endocrine pancreas development; G-protein coupled receptor protein signaling pathway; positive regulation of protein kinase B signaling cascade; cellular protein metabolic process; fatty acid homeostasis; positive regulation of glycolysis; insulin receptor signaling pathway; energy reserve metabolic process; positive regulation of insulin receptor signaling pathway; regulation of insulin secretion; positive regulation of DNA replication; positive regulation of cell migration; positive regulation of cytokine secretion. Disease: Diabetes Mellitus, Insulin-dependent, 2; Diabetes Mellitus, Permanent Neonatal; Hyperproinsulinemia; Maturity-onset Diabetes Of The Young, Type 10

0.1毫克

280美元

0.2毫克

385