抗体

兔抗CD31(PECAM1)多克隆

MBS551038

0.1毫克

280美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠

免疫印迹, 酶联免疫吸附测定, 免疫组化, 酶免疫法

抗体

兔抗CD31(PECAM1)多克隆

CD31(PECAM1)

兔抗CD31多克隆纯化;pecam1;血小板-内皮细胞粘附分子1;cd31;Coding sequence蛋白质编码序列31;多克隆;多克隆抗体

血小板内皮细胞 粘连分子;血小板内皮细胞 粘连分子;EndoCAM;GPIIA';PECA1

CD31

PECAM1;PECAM-1

PECA1_HUMAN

多克隆

IgG

兔

人类, 小鼠, 大鼠

738

>95%

冻干来自0.2um选择溶液在PBS pH7.4

The lyophilized antibody is stable for at least 1 year from date of receipt at -20 degree C. Upon reconstitution, this antibody can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months without detectable loss of activity. Avoid repeated freeze/thaw cycles. Shelf Life: >12 months

免疫印迹(免疫印迹), 免疫组化(免疫组化), 酶联免疫吸附测定(EIA)

ELISA: Use at a concentration range of 1-2ug/ml. Western blot:A suitable range of concentrations of this antibody for WB detection is 2-10 ug/ml. IHC: A suitable range of concentrations of this antibody for IHC is 2-10 ug/ml. Immunohistochemical analysis of CD31-positive microvessels in FFPE Human malignant melanoma cell line, A375. It was used as primary antibody, dilution 1:200, DAB chromogen substrate. Immunohistochemical analysis of mouse CD31 expression in FFPE vascular endothelial melanoma cell. It was used as primary antibody, dilution 1:200, DAB chromogen substrate.

Source Note: PolyclonalCD31 antibody was produced from sera of rabbits immunized with synthetic protein containing CD31 antigenic determinants.

Reconstitution: A quick spin of the vial followed by reconstitution in distilled water. This solution can then be diluted into other buffers. Dilution: a quick spin of the vial followed by reconstitution in 0.01M PBS pH 7.4 or other diluents.

多克隆

Platelet endothelial cell adhesion molecule (PECAM-1, CD31) is a 130 kD glycoprotein that is constitutively expressed by endothelial cells and by platelets, neutrophils, monocytes, and some T- lymphocytes. It is an integral transmembrane protein that belongs to the immunoglobulin superfamily and that mediates both homotypic and heterotypic cell adhesion. These functions have implicated CD31 in a variety of important biological processes including inflammation, angiogenesis and wound healing.In particular, CD31 has an important role in neutrophil and monocyte emigration across vascular endothelium, processes that can be inhibited, both in vitro and in vivo, with anti-CD31 antibodies.

prognostic and predictive impact of expression of the angiogenic markers cd105 and CD31 expression in patients with high risk breast cancer (hrbc). . Cancer Res., Dec 2009; 69: 2154. cd38/ CD31 , the ccl3 and ccl4 chemokines, and cd49d/vascular cell adhesion molecule-1 are interchained by sequential events sustaining chronic lymphocytic leukemia cell survival . Cancer Res., May 2009; 69: 4001 - 4009. circulating monocytes expressing CD31 : implications for acute and chronic angiogenesis . Am. J. Pathol., May 2009; 174: 1972 - 1980. il-7 sustains CD31 expression in human naive cd4+ t cells and preferentially expands the CD31 + subset in a pi3k-dependent manner . Blood, Mar 2009; 113: 2999 - 3007. transcriptional profiling of CD31 + cells isolated from murine embryonic stem cells . Genes Cells, Feb 2009; 14: 243 - 260.

313760624

NP_000433.4

NM_000442.4

P16284

Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Cell Surface Interactions At The Vascular Wall Pathway (106062); Formation Of Platelet Plug Pathway (106029); Hemostasis Pathway (106028); Integrin Cell Surface Interactions Pathway (106110); Leukocyte Transendothelial Migration Pathway (83083); Leukocyte Transendothelial Migration Pathway (494); Malaria Pathway (152665); Malaria Pathway (152657)

The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010]

PECAM-1: a cell adhesion molecule expressed on platelets and at endothelial cell intercellular junctions. Plays a role in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, cell migration, negative regulation of immune cell signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. Undergoes alternative splicing, generating multiple isoforms in vascular beds of various tissues. Protein type: Cell adhesion; Membrane protein, integral. Chromosomal Location of Human Ortholog: 17q23.3. Cellular Component: extracellular space; platelet alpha granule membrane; plasma membrane; integral to membrane; cell junction. Molecular Function: protein binding. Biological Process: platelet activation; extracellular matrix organization and biogenesis; platelet degranulation; diapedesis; cell recognition; signal transduction; blood coagulation; cell adhesion; leukocyte migration; phagocytosis

0.1毫克

280美元

0.2毫克

385