产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
兔抗IL-18多克隆
目录 :
MBS551052
规格 :
0.1毫克
价格 :
280美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 酶免疫法
更多信息或购买 :
产品信息
目录号 :
MBS551052
产品类型 :
抗体
产品全称 :
兔抗IL-18多克隆
产品简称 :
IL-18
产品名称同义词 :
兔抗IL-18多克隆纯化;IGIF;IL1F4;白细胞介素-18;白细胞介素18;多克隆;多克隆抗体
其他名称 :
interleukin-18 isoform 2 proprotein; Interleukin-18; Iboctadekin; Interferon gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma
产品基因名称 :
IL-18
其他基因名称 :
IL18; IGIF; IL1F4; IL-18; IFN-gamma-inducing factor; IL-1 gamma
UniProt数据库进入名 :
IL18_HUMAN
克隆性 :
多克隆
抗体亚型 :
IgG
宿主 :
Polyclonal anti IL-18 was produced from sera of rabbits immunized with synthetic protein containing IL-18 C Terminal antigenic determinants.
反应物种 :
人类, 小鼠, 大鼠
序列长度 :
189
纯度 :
Serum IgG fraction was purified by Protein G affinity chromatography. Purity: >95%
储存稳定性 :
The lyophilized antibody is stable for at least 1 year from date of receipt at -20 degree C. Upon reconstitution, this antibody can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months without detectable loss of activity. Avoid repeated freeze/thaw cycles. Shelf Life: >12 months
检测过的应用 :
免疫印迹(免疫印迹), 免疫组化(免疫组化), 酶联免疫吸附测定(EIA)
应用笔记 :
ELISA: Use at a concentration range of 1-2ug/ml. Western blot: Use at a concentration range of 2-10 ug/ml. Immunohistochemical (IHC): A suitable range of concentrations of this antibody for IHC is 2-10 ug/ml.
其它信息1 :
Source Note: Polyclonal Interleukin-18 antibody was produced from sera of rabbits immunized with synthetic protein containing Interleukin-18 N-terminus antigenic determinants.
其他信息2 :
Reconstitution: A quick spin of the vial followed by reconstitution in distilled water. This solution can then be diluted into other buffers. Dilution: A quick spin of the vial followed by reconstitution in 0.01M PBS pH 7.4 or other diluents. Presentation: 0.2 um filtered 1mg/ml solution in TBS pH 7.4, 50% glycerol, 1% BSA, 0.03% proclin.
产品种类 :
多克隆
产品描述 :
IL18 is synthesized as a biologically inactive precursor protein that has limited biological activity. The proform of IL18 is processed by one of the caspases, Caspase-1, to generate the 18 kDa bioactive molecule. IL-18 is produced during the acute immune response by macrophages and immature dendritic cells. Interleukin-18 is expressed by a variety of immune and non-immune cells, including monocytes and macrophages. IL18 is one of the pro- inflammatory cytokines. The activities of IL18 appear to be species specific. An important function of IL18 is the regulation of functionally distinct subsets of T-helper cells required for cell mediated immune responses (Nakanishi et al, 2001). IL18 functions as a growth and differentiation factor for Th1 cells. IL18 up-regulates FAS ligand mediated cytotoxic activitiy of murine natural killer cells. IL-18 is part of a complex regulatory circuit involved in causing cell death by apoptosis.
产品引用 :
IL-18 binding protein-expressing mesenchymal stem cells improve myocardial protection after ischemia or infarction . PNAS, Sep 2009; 10.1073/pnas.0908924106. IL-18 and urinary ngal predict dialysis and graft recovery after kidney transplantation . J. Am. Soc. Nephrol., Sep 2009; 10.1681/ASN.2009030264. a functional polymorphism in IL-18 is associated with severity of bronchial asthma . Am. J. Respir. Crit. Care Med., Sep 2009; 10.1164/rccm.200905-0652 degree C. il-12p40 and IL-18 play pivotal roles in orchestrating the cell-mediated immune response to a poxvirus infection . J. Immunol., Sep 2009; 183: 3324 - 3331. neutrophil chemokines and their role in IL-18 -mediated increase in neutrophil o2 production and intestinal edema following alcohol intoxication and burn injury . Am J Physiol Gastrointest Liver Physiol, Aug 2009; 297: G340 - G347.
NCBI GI登录号 :
342349321
NCBI登录号 :
NP_001230140.1
NCBI基因登录号 :
NM_001243211.1
UniProt数据库登录号 :
Q14116
NCBI分子量 :
22,326 Da
NCBI信号通路 :
African Trypanosomiasis Pathway (194384); African Trypanosomiasis Pathway (194323); Cellular Roles Of Anthrax Toxin Pathway (138076); Cytokine Signaling In Immune System Pathway (366171); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Cytosolic DNA-sensing Pathway (125137); Cytosolic DNA-sensing Pathway (124833); Hypertrophy Model Pathway (198828); IL12 Signaling Mediated By STAT4 Pathway (137936)
NCBI总结 :
The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]
UniProt数据库总结 :
IL18: Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. Belongs to the IL-1 family. Protein type: Cytokine. Chromosomal Location of Human Ortholog: 11q22.2-q22.3. Cellular Component: extracellular space; extracellular region; cytosol. Molecular Function: protein binding; cytokine activity. Biological Process: positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of NK T cell proliferation; natural killer cell activation; positive regulation of NF-kappaB import into nucleus; positive regulation of activated T cell proliferation; chemokine biosynthetic process; cell-cell signaling; lipopolysaccharide-mediated signaling pathway; granulocyte macrophage colony-stimulating factor biosynthetic process; angiogenesis; inflammatory response; positive regulation of interleukin-17 production; regulation of cell adhesion; T-helper 1 type immune response; positive regulation of natural killer cell proliferation; T-helper 2 type immune response; interleukin-2 biosynthetic process; MAPKKK cascade; interleukin-13 biosynthetic process; sleep; positive regulation of interferon-gamma production; positive regulation of tissue remodeling; interferon-gamma biosynthetic process; immune response; negative regulation of myoblast differentiation; positive regulation of inflammatory response
尺寸1 :
0.1毫克
价格1 :
280美元
尺寸2 :
0.2毫克
价格2 :
385
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。