[alpha-1-antichymotrypsin; Alpha-1-antichymotrypsin; alpha-1-antichymotrypsin; serpin A3; OTTHUMP00000028439; growth-inhibiting protein 24; growth-inhibiting protein 25; cell growth-inhibiting gene 24/25 protein; serine (or cysteine) proteinase inhibitor, clade A, member 3; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3; Cell growth-inhibiting gene 24/25 protein; Serpin A3]
Store at 4 degree C. Shelf Life: 24 months after shipping date.
This product is specific for alpha 1-Antichymotrypsin by ELISA, immunodiffusion and IEP analysis. No reaction with other human proteins is observed.
Buffer: Phosphate buffered saline, pH 7.2
Preservative: 0.1% sodium azide. Procedure: Goats were immunized using purified human alpha 1-Antichymotrypsin as the immunogen. To ensure specificity the resulting antiserum was solid phase absorbed and affinity purified off an antigen containing immunoabsorbant.
Goats were immunized with highly purified human Alpha 1-Antichymotrypsin. The resulting antiserum was passed over an antigen containing immunoabsorbant from which the anti-human Alpha 1-Antichymotrypsin was immunoaffinity purified.
NCBI GI登录号 :
The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. [provided by RefSeq]
SERPINA3: Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. Belongs to the serpin family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 14q32.1. Cellular Component: extracellular space; extracellular region; intracellular; nucleus. Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; DNA binding. Biological Process: regulation of lipid metabolic process; maintenance of gastrointestinal epithelium; acute-phase response; inflammatory response
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