抗体

单克隆抗体抗人类GM-CSF

MBS592011

0.5毫克

465美元

单克隆

小鼠

未共轭

S333

酶联免疫吸附测定, 酶免疫法

抗体

单克隆抗体抗人类GM-CSF

GM-CSF

粒细胞巨噬细胞集落刺激因子(GM-CSF);小鼠单克隆抗体人类粒细胞巨噬细胞集落刺激因子(GM-CSF)

GM-CSF; Granulocyte-macrophage colony-stimulating factor; granulocyte-macrophage colony-stimulating factor; CSF; granulocyte macrophage-colony stimulating factor; molgramostin; sargramostim; colony stimulating factor 2 (granulocyte-macrophage); Colony-stimulating factor; CSF; Molgramostin; Sargramostim

GM-CSF

CSF2;CSF2;GMCSF

CSF2_HUMAN

单克隆

IgG1, k

S333

小鼠

Human. Other species not tested. Does not show any cross reaction with other human cytokines or growth factors tested such as M-CSF, G-CSFR, IL-8, IL-16, IL-1beta, TGF-beta1 and TNF-alpha.

144

Reacts with natural and recombinant human Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF)

蛋白质G亲和纯化

冻干来自a溶液在0.01M PBS, pH值7.2

Store at -20 degree C

酶联免疫吸附测定(EIA)

Target Protein: Human GM-CSF. Immunogen: Purified recombinant human GM-CSF. Myeloma: Sp2/0-Ag14. Light Chain: Kappa. Reconstitution: Double distillated water is recommended to reconstitute the antibody.

Research Area: Hematopoiesis, infection

Primary antibodies; Monoclonal Antibodies to Human Cytokines and Growth Factors

Mouse monoclonal antibody to human granulocyte macrophage colony stimulating factor (GMCSF), Protein G affinity purified. GM-CSF is an extracellular homodimer polyprotein, functioning as a hematopoietic growth factor and immune modulator. It can be produced and act upon a variety of cell types, including T-lymphocytes, Blymphocytes, monocytes/macrophages, endothelial cells, fibroblasts, stromal cells, mesothelial cells, keratinocytes, osteoblasts, uterine epithelial cells, synoviocytes, mast cells and various solid tumors. GM-CSF stimulates stem cells to produce granulocytes and monocytes to cope with infection. Recombinant GM-CSF has been applied to boost white blood cell in cancer patients after chemotherapy and may also be useful as an immune tonic for anemia and AIDS patients.

183364

AAA52578.1

16,295 Da

Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway (137993); Calcium Signaling In The CD4+ TCR Pathway (137941); Cytokine Signaling In Immune System Pathway (366171); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Cytokines And Inflammatory Response Pathway (198794); Fc Epsilon RI Signaling Pathway (83082); Fc Epsilon RI Signaling Pathway (493)

The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008]

GMCSF: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. Belongs to the GM-CSF family. Protein type: Cytokine; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 5q31.1. Cellular Component: extracellular space; extracellular region. Molecular Function: protein binding; growth factor activity; granulocyte macrophage colony-stimulating factor receptor binding; cytokine activity. Biological Process: negative regulation of cytolysis; epithelial fluid transport; embryonic placenta development; macrophage activation; positive regulation of tyrosine phosphorylation of Stat5 protein; positive regulation of interleukin-23 production; positive regulation of cell proliferation; immune response; myeloid dendritic cell differentiation; positive regulation of DNA replication

0.5毫克

465美元