产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
单克隆抗体抗人类bata2微球蛋白
目录 :
MBS592049
规格 :
0.5毫克
价格 :
445美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
[D2A10]
反应物种 :
人类
应用 :
酶联免疫吸附测定, 酶免疫法
更多信息或购买 :
图像
图像 1 :
Detect 100 ng recombinant human B2MG antigen (right lane) using anti-human B2MG mAb D2A10 at 1 ug/mL dilution
图像 2 :
Stainning of methanol-fixed Hela cells: Mouse anti-Human beta 2 Microglobulin monoclonal antibody
(D2A10) 1:50 (20ug/mL).
图像 3 :
Is the histogram of Mouse anti-Human beta 2 Micro Globulin monoclonal antibody 1:100 (10ug/mL) staining of Hela cells. Black line histogram represents the isotype control, Mouse anti-TB 38Kd antigen monoclonal antibody (MBS592053, B12F8).
产品信息
目录号 :
MBS592049
产品类型 :
抗体
产品全称 :
单克隆抗体抗人类bata2微球蛋白
产品简称 :
[bata2微球蛋白]
产品名称同义词 :
[bata2微球蛋白;小鼠单克隆抗体人类bata2微球蛋白(B2毫克)]
其他名称 :
[beta-2-microglobulin; Beta-2-microglobulin; beta-2-microglobulin; beta chain of MHC class I molecules; beta-2-microglobin; beta-2-microglobulin]
其他基因名称 :
[B2M;B2M]
UniProt数据库进入名 :
B2 MG_HUMAN
克隆性 :
单克隆
抗体亚型 :
IgG1, k
克隆 :
[D2A10]
宿主 :
小鼠
反应物种 :
Human. Others not tested
序列长度 :
119
特异性 :
bata2微球蛋白
纯度 :
蛋白质G亲和纯化
形式 :
冻干来自a溶液在0.01M PBS, pH值7.2
储存稳定性 :
存放在-20°C
检测过的应用 :
酶联免疫吸附测定(EIA)
应用笔记 :
ELISA:抗体反应对象人类B2毫克
image1头 :
免疫印迹
image2头 :
Immunofluorescent
image3头 :
流式细胞仪
其它信息1 :
Target Protein: Human beta 2 microglobulin (B2MG)
. Immunogen: Highly purified beta 2 microglobulin from human urine. Fusion Myeloma: Sp2/0-Ag14
. Light Chain: Kappa
. Reconstitution: Double distilled water is recommended to reconstitute the antibody.
其他信息2 :
Research Area: Renal disease, plasma cell cancer
产品种类 :
Primary antibody; Monoclonal Antibodies to Human Inflammatory Proteins
产品描述 :
Human beta 2 microglobulin (B2MG) is a component of major histocompatibility complex 1 (MHC1). It is abundant at the surface of lymphocytes and exists at the surface of all cell types except red cells and platelets. B2MG is normally filtered out of blood through glomeruli, but the process is impaired in patients with renal diseases. Elevated B2MG level is implicated with lymphoma, multiple myeloma, renal diseases, viral infections and auto-immune conditions.
NCBI GI登录号 :
4757826
NCBI登录号 :
NP_004039.1
NCBI基因登录号 :
NM_004048.2
NCBI信号通路 :
Adaptive Immune System Pathway (366160); Amyloids Pathway (366238); Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway (366163); Antigen Processing And Presentation Pathway (83074); Antigen Processing And Presentation Pathway (485); Antigen Processing-Cross Presentation Pathway (477122); Class I MHC Mediated Antigen Processing Presentation Pathway (366161); Cytokine Signaling In Immune System Pathway (366171); DAP12 Interactions Pathway (685549); DAP12 Signaling Pathway (685550)
NCBI总结 :
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014]
UniProt数据库总结 :
B2M: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Heterodimer of an alpha chain and a beta chain. Beta-2- microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. Belongs to the beta-2-microglobulin family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 15q21.1. Cellular Component: Golgi membrane; Golgi apparatus; extracellular space; phagocytic vesicle membrane; focal adhesion; membrane; early endosome membrane; endoplasmic reticulum lumen; cytoplasm; plasma membrane; extracellular region; MHC class I protein complex; external side of plasma membrane. Molecular Function: identical protein binding; protein binding. Biological Process: response to drug; regulation of immune response; viral reproduction; positive regulation of T cell mediated cytotoxicity; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; cytokine and chemokine mediated signaling pathway; T cell differentiation in the thymus; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of defense response to virus by virus; retinal homeostasis; antigen processing and presentation of peptide antigen via MHC class I; iron ion homeostasis; response to cadmium ion; response to molecule of bacterial origin; innate immune response; antigen processing and presentation of exogenous peptide antigen via MHC class I; protein refolding; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent. Disease: Hypoproteinemia, Hypercatabolic
尺寸1 :
0.5毫克
价格1 :
445美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华，公司愿景是“生物研究试剂的源头”，现在位于圣地亚哥市。