抗体

PEMT, NT(PEMT, PEMPT, PNMT, 磷脂酰乙醇胺-N-甲基转移酶, PEMT2)

MBS6004399

0.2毫升

500美元

多克隆

兔

未共轭

人类, 小鼠

免疫印迹, 酶联免疫吸附测定, 免疫组化, 酶免疫法

抗体

PEMT, NT(PEMT, PEMPT, PNMT, 磷脂酰乙醇胺-N-甲基转移酶, PEMT2)

PEMT

抗-PEMT, NT(PEMT, PEMPT, PNMT, 磷脂酰乙醇胺-N-甲基转移酶, PEMT2)

phosphatidylethanolamine N-methyltransferase isoform 3; Phosphatidylethanolamine N-methyltransferase; phosphatidylethanolamine N-methyltransferase; phosphatidylethanolamine N-methyltransferase; PEMT2

PEMT;PEMT;PNMT;PEAMT;PEMPT;PEMT2;PEMPT;PNMT;PEAMT;PEMT

PEMT_HUMAN

多克隆

IgG

兔

小鼠

Recognizes human PEMT. Species Crossreactivity: mouse

Affinity Purified. Purified by ammonium sulfate precipitation

以溶解在PBS液体方式提供, pH值7.2, 0.09% 叠氮化钠

2.12毫克/毫升

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

酶联免疫吸附测定(EL/EIA), 免疫印迹(免疫印迹), 免疫组化(免疫组化)

Suitable for use in Western Blot, Immunohistochemistry, ELISA. Dilution: Western Blot: 1:1,000; Immunohistochemistry (FFPE): 1:10-50

Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 1-30 in the N-terminal region of human PEMT, UniProt Accession #Q9UBM1

Grade: Purified

Antibodies; Abs to Enzymes, Methyltransferase

This gene encodes an enzyme which converts phosphatidylethanolamine to phosphatidylcholine by sequential methylation in the liver. The protein localizes to the endoplasmic reticulum and mitochondria-associated membranes. The gene is within the Smith-Magenis syndrome region on chromosome 17. Alternate splicing of this gene results in three transcript variants encoding two different isoforms.

388890237

NP_001254481.1

NM_001267552.1

Q9UBM1

22,134 Da

Acetylcholine Synthesis Pathway (198820); Glycerophospholipid Biosynthesis Pathway (645313); Glycerophospholipid Metabolism Pathway (82989); Glycerophospholipid Metabolism Pathway (364); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); Phosphatidylcholine (PC) Biosynthesis, PE = PC Pathway (695051); Phosphatidylcholine (PC) Biosynthesis, PE = PC Pathway (468284); Phospholipid Metabolism Pathway (645312); Synthesis Of PC Pathway (645319)

Phosphatidylcholine (PC) is the most abundant mammalian phospholipid. This gene encodes an enzyme which converts phosphatidylethanolamine to phosphatidylcholine by sequential methylation in the liver. Another distinct synthetic pathway in nucleated cells converts intracellular choline to phosphatidylcholine by a three-step process. The protein isoforms encoded by this gene localize to the endoplasmic reticulum and mitochondria-associated membranes. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2012]

PEMT iso2: Catalyzes three sequential methylation reactions of phosphatidylethanolamine (PE) by AdoMet, thereby producing phosphatidylcholine (PC). Belongs to the PEMT/PEM2 methyltransferase family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Lipid Metabolism - glycerophospholipid; Endoplasmic reticulum; Membrane protein, multi-pass; Mitochondrial; Methyltransferase; Membrane protein, integral; EC 2.1.1.71; EC 2.1.1.17. Chromosomal Location of Human Ortholog: 17p11.2. Cellular Component: endoplasmic reticulum membrane; mitochondrial membrane; integral to membrane. Molecular Function: phosphatidyl-N-methylethanolamine N-methyltransferase activity; phosphatidylethanolamine N-methyltransferase activity. Biological Process: methylation; cell proliferation; phospholipid metabolic process; glycerophospholipid biosynthetic process; phosphatidylcholine biosynthetic process; lipid metabolic process

0.2毫升

500美元