产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
CXCR7(C-X趋化因子受体7, 趋化因子孤儿受体1, RDC-1)
目录 :
MBS600631
规格 :
0.1毫克
价格 :
575美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
8B9
反应物种 :
人类
应用 :
免疫组化, 流式细胞仪, 流式细胞仪
更多信息或购买 :
产品信息
目录号 :
MBS600631
产品类型 :
抗体
产品全称 :
CXCR7(C-X趋化因子受体7, 趋化因子孤儿受体1, RDC-1)
产品简称 :
CXCR7
产品名称同义词 :
抗-CXCR7(C-X趋化因子受体7, 趋化因子孤儿受体1, RDC-1)
其他名称 :
C-X-C chemokine receptor type 7; C-X-C chemokine receptor type 7; C-X-C chemokine receptor type 7; RDC-1; CXC-R7; CXCR-7; OTTHUMP00000164411; G protein-coupled receptor; chemokine orphan receptor 1; G-protein coupled receptor 159; G-protein coupled receptor RDC1 homolog; chemokine (C-X-C motif) receptor 7; Chemokine orphan receptor 1; G-protein coupled receptor 159; G-protein coupled receptor RDC1 homolog
其他基因名称 :
CXCR7;CXCR7;RDC1;CMKOR1;GPR159;CMKOR1;GPR159;RDC1
UniProt数据库进入名 :
CXCR7_HUMAN
克隆性 :
单克隆
抗体亚型 :
IgG1
克隆 :
8B9
宿主 :
小鼠
反应物种 :
人类
特异性 :
Recognizes human CXCR7. Reacts with five distinct human CXCR7 transfectants, but not their respective parental lines. Also reacts with MCF-7 cells expression of CXCR7.
纯度 :
Affinity Purified. Purified by Protein G affinity chromatography.
形式 :
Supplied as a lyophilized powder from PBS, 7.4, 5% trehalose. Reconstitute with 200ul sterile PBS.
储存稳定性 :
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
检测过的应用 :
免疫组化(免疫组化), 流式细胞仪(FC/流式细胞仪)
应用笔记 :
Dilution: Flow Cytometry: 2.5ug labels 10e6 cells in the MCF-7 human breast cancer cell line. Immunohistochemistry (Paraffin): 8-25ug/ml. Detected CXCR7 in paraffin sections of nude mice injected with human breast cancer cells.
其它信息1 :
Immunogen: Human CXCR7 encoding plasmid (Accession #P25106)
产品种类 :
Antibodies; Abs to Growth Factors, Cytokines
产品描述 :
The G protein-coupled receptor, RDC1, belongs to a subgroup of chemokine receptors and has been designated CXCR7. CXCR7 can bind with high-affinity to CXCL12/SDF-1 and CXCL11/I-TAC. It is also a co-receptor for several HIV and SIV strains. In their N-termini and extracellular loops 1, 2 and 3, human and mouse CXCR7 share 84%, 100%, 96% and 86% amino acid sequence identity, respectively. Reports of mRNA levels and/or protein expression indicate that CXCR7 occurs on a wide variety of tissues and cells including monocytes, B cells, T cells and mature dendritic cells. In contrast, based on ligand binding analysis and receptor level (assessed using anti-CXCR7, clone 11G8), surface expression of CXCR7 was reported to be restricted to tumor cells, activated endothelial cells, fetal liver cells and few other cell types. The basis of these inconsistent observations is not known but may be attributed to cell context and the use of different antibodies that may recognize different epitopes.
NCBI GI登录号 :
31083344
NCBI登录号 :
NP_064707.1
NCBI基因登录号 :
NM_020311.2
UniProt数据库登录号 :
P25106
NCBI分子量 :
41,493 Da
NCBI信号通路 :
Chemokine Receptors Bind Chemokines Pathway (106359); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); G Alpha (i) Signalling Events Pathway (119550); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); GPCRs, Class A Rhodopsin-like Pathway (198886); Myometrial Relaxation And Contraction Pathways (198759); Peptide Ligand-binding Receptors Pathway (106358)
NCBI总结 :
This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. [provided by RefSeq]
UniProt数据库总结 :
CMKOR1: Receptor for chemokines CXCL12/SDF1 and CXCL11. Does not elicit classical chemokine receptor signaling; chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Acts as a scavenger for CXCL12/SDF1 and, to a lesser extent, for CXCL11. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates. Belongs to the G-protein coupled receptor 1 family. Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral. Chromosomal Location of Human Ortholog: 2q37.3. Cellular Component: recycling endosome; cell surface; perinuclear region of cytoplasm; early endosome; plasma membrane; integral to membrane; coated pit; endosome. Molecular Function: C-X-C chemokine binding; protein binding; coreceptor activity; scavenger receptor activity; C-X-C chemokine receptor activity. Biological Process: G-protein coupled receptor protein signaling pathway; viral reproduction; receptor internalization; angiogenesis; chemotaxis; vasculogenesis; cell adhesion
尺寸1 :
0.1毫克
价格1 :
575美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。