产品简要
公司名称 :
MyBioSource
产品类型 :
其他
产品名称 :
Mouse Anti-Human HLA Class 1 Antigen A30,A31 (R0.87)
目录 :
MBS600673
规格 :
0.1毫升
价格 :
440美元
更多信息或购买 :
图像
图像 1 :
MyBioSource MBS600673 图像 1
产品信息
目录号 :
MBS600673
产品类型 :
抗体
产品全称 :
Mouse Anti-Human HLA Class 1 Antigen A30,A31 (R0.87)
产品简称 :
[HLA Class 1 Antigen A30,A31]
产品名称同义词 :
[Anti -HLA Class 1 Antigen A30,A31 (R0.87)]
其他名称 :
[HLA-A31, partial; HLA class I histocompatibility antigen, A-68 alpha chain; HLA class I histocompatibility antigen, A-1 alpha chain; antigen presenting molecule; leukocyte antigen class I-A; MHC class I antigen HLA-A heavy chain; major histocompatibility complex, class I, A; Aw-68; HLA class I histocompatibility antigen, A-28 alpha chain; MHC class I antigen A*68]
其他基因名称 :
[HLA-A;HLA-A;HLAA;HLAA]
UniProt数据库进入名 :
1A68_HUMAN
抗体亚型 :
IgM
克隆 :
[4i103]
特异性 :
Recognizes human HLA Class 1 Antigen-A30,A31. Specificity was determined at a 1:10 dilution by the microcytotoxicity test under standard NIH conditions.
纯度 :
腹水
形式 :
Supplied as a lyophilized powder from PBS, 1% BSA. Reconstitute to 100ul with sterile ddH2O to make a 10X stock solution.
储存稳定性 :
Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
检测过的应用 :
This antibody has not been tested in methodologies other than Microcytotoxicity Test. Potential applications include Flow Cytometry, Cell Typing, Tissue Staining and Chimerism Studies.
应用笔记 :
Cytoxicity: Add 0.9 mL of PBS, 1% BSA to 100 uL of 10x Stock solution. Optimal dilutions to be determined by the researcher.
image1头 :
试验数据
其它信息1 :
Immunogen: HLA Class 1 Antigen-A30, A31.
产品种类 :
Antibodies; Abs to HLA
产品描述 :
The human leukocyte antigen system (HLA) is the name of the major histocompatibility complex (MHC) in humans and is an essential element for immune function. This group of genes re- sides on chromosome 6, and encodes cell-surface antigen- presenting proteins and many other genes. Different classes have different functions: HLA class I antigens (A, B & C) present peptides from inside the cell, including viral peptides if present. These peptides are produced from digested proteins that are broken down in the proteasomes. Foreign antigens attract killer T-cells (also called CD8+ or cytotoxic T-cells) that destroy cells.
NCBI GI登录号 :
386879
NCBI登录号 :
AAA59613.1
UniProt数据库登录号 :
P01891
NCBI信号通路 :
Adaptive Immune System Pathway (366160); Allograft Rejection Pathway (83123); Allograft Rejection Pathway (535); Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway (366163); Antigen Processing And Presentation Pathway (83074); Antigen Processing And Presentation Pathway (485); Antigen Processing-Cross Presentation Pathway (477122); Autoimmune Thyroid Disease Pathway (83121); Autoimmune Thyroid Disease Pathway (533); Cell Adhesion Molecules (CAMs) Pathway (83069)
NCBI总结 :
HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
HLAA: Involved in the presentation of foreign antigens to the immune system. Belongs to the MHC class I family. Protein type: Immunoglobulin superfamily; Membrane protein, integral. Chromosomal Location of Human Ortholog: 6p21.3. Cellular Component: Golgi membrane; Golgi apparatus; phagocytic vesicle membrane; cell surface; membrane; integral to plasma membrane; endoplasmic reticulum; early endosome membrane; plasma membrane; MHC class I protein complex; Golgi medial cisterna. Molecular Function: protein binding; peptide antigen binding; beta-2-microglobulin binding; T cell receptor binding; TAP binding; receptor binding. Biological Process: regulation of immune response; viral reproduction; detection of bacterium; positive regulation of T cell mediated cytotoxicity; cytokine and chemokine mediated signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; protection from natural killer cell mediated cytotoxicity; regulation of defense response to virus by virus; positive regulation of interferon-gamma production; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of exogenous peptide antigen via MHC class I; immune response. Disease: Severe Cutaneous Adverse Reaction, Susceptibility To
尺寸1 :
0.1毫升
价格1 :
440美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。