产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
CD44S (HCAM, Homing Cell Adhesion Molecule, Pgp-1, Phagocytic Glycoprotein-1, Hermes Antigen, Lymphocyte Homing Receptor, ECM-III, HUTCH-1)
目录 :
MBS601058
规格 :
0.1毫克
价格 :
680美元
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
未共轭
克隆名称 :
[2Q1374]
反应物种 :
人类, 小鼠, 大鼠, ,
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 流式细胞仪, 放射免疫分析法, 酶免疫法
更多信息或购买 :
产品信息
目录号 :
MBS601058
产品类型 :
抗体
产品全称 :
CD44S (HCAM, Homing Cell Adhesion Molecule, Pgp-1, Phagocytic Glycoprotein-1, Hermes Antigen, Lymphocyte Homing Receptor, ECM-III, HUTCH-1)
产品简称 :
[CD44S]
产品名称同义词 :
[Anti -CD44S (HCAM, Homing Cell Adhesion Molecule, Pgp-1, Phagocytic Glycoprotein-1, Hermes Antigen, Lymphocyte Homing Receptor, ECM-III, HUTCH-1)]
其他名称 :
[CD44 antigen; CD44 antigen; CD44 antigen; epican; Hermes antigen; hyaluronate receptor; phagocytic glycoprotein 1; heparan sulfate proteoglycan; cell surface glycoprotein CD44; extracellular matrix receptor III; chondroitin sulfate proteoglycan 8; GP90 lymphocyte homing/adhesion receptor; hematopoietic cell E- and L-selectin ligand; homing function and Indian blood group system; CD44 molecule (Indian blood group); CDw44; Epican; Extracellular matrix receptor III; ECMR-III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; Heparan sulfate proteoglycan; Hermes antigen; Hyaluronate receptor; Phagocytic glycoprotein 1; PGP-1; Phagocytic glycoprotein I]
其他基因名称 :
[CD44;CD44;在;LHR;MC56;MDU2;MDU3;MIC4;Pgp1;CDW44;CSPG8;HCELL;HUTCH-I;ECMR-III;LHR;MDU2;MDU3;MIC4;ECMR-III;PGP-1;PGP-I]
UniProt数据库进入名 :
CD44_HUMAN
克隆性 :
单克隆
抗体亚型 :
IgG2b
克隆 :
[2Q1374]
宿主 :
大鼠
反应物种 :
牛, 狗, 人类, 小鼠, 猪, 兔, 大鼠
特异性 :
Recognizes human CD44 (85-95kD) gp90 Hermes and mouse gp85 (Pgp-1). Reacts with the standard CD44 isoform that lacks exon sequences v1-v10. Species Crossreactivity: rabbit, porcine, mouse, rat, canine, bovine cells/tissue
纯度 :
纯化。 纯化
形式 :
以溶解在PBS液体方式提供, pH值7.5, 0.01% 叠氮化钠
浓度 :
1毫克/毫升
储存稳定性 :
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
检测过的应用 :
酶联免疫吸附测定(EL/EIA), 免疫印迹(免疫印迹), 免疫沉淀(免疫沉淀), 免疫组化(免疫组化), 流式细胞仪(FC/流式细胞仪), 免疫荧光(IF), 放射免疫分析法(RIA)
应用笔记 :
Suitable for use in ELISA, RIA, Flow Cytometry, Immunoflourescence, Western Blot, Immunohistochemistry and Immunoprecipitation. Dilution: ELISA: 1:2000. RIA: 1:5000. Flow Cytometry: 1:1000. Immunoflourescence: 1:200. Immunohistochemistry (Paraffin): 1:250 Antigen retrieval is usually not needed. Immunoprecipitation: 1:200. Western Blot: 1:1000. Non-reduced only. ~90kD band detected; Blocking PBS/5% milk protein. Overnight incubation.
其它信息1 :
Immunogen: Purified human blood lymphocyte CD44
产品种类 :
Antibodies; Abs to CD Markers
产品描述 :
CD44 (H-CAM, Homing Cell Adhesion Molecule) is a 85-90kD transmembrane protein. The human CD44 gene contains 19 exons; 1-5 and 15-19 are expressed by wild-type CD44, also known as the standard hemopoietic form (CD44s).
NCBI GI登录号 :
308153615
NCBI登录号 :
P16070.3
UniProt数据库登录号 :
P16070
NCBI分子量 :
81,538 Da
NCBI信号通路 :
Cytokine Signaling In Immune System Pathway (366171); Disease Pathway (530764); ECM-receptor Interaction Pathway (83068); ECM-receptor Interaction Pathway (479); Epstein-Barr Virus Infection Pathway (585562); Epstein-Barr Virus Infection Pathway (587115); Extracellular Matrix Organization Pathway (576262); Glycosaminoglycan Metabolism Pathway (645297); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489)
NCBI总结 :
The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
CD44: Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Interacts with PKN2. Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment. Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment. Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells. 19 isoforms of the human protein are produced by alternative splicing. Protein type: Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 11p13. Cellular Component: Golgi apparatus; focal adhesion; cell surface; basolateral plasma membrane; integral to plasma membrane; cytoplasm; plasma membrane; external side of plasma membrane. Molecular Function: collagen binding; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; hyaluronic acid binding; hyalurononglucosaminidase activity. Biological Process: extracellular matrix organization and biogenesis; Wnt receptor signaling pathway; positive regulation of heterotypic cell-cell adhesion; glycosaminoglycan metabolic process; cytokine and chemokine mediated signaling pathway; cell-matrix adhesion; pathogenesis; negative regulation of caspase activity; positive regulation of peptidyl-serine phosphorylation; hyaluronan catabolic process; extracellular matrix disassembly; negative regulation of DNA damage response, signal transduction by p53 class mediator; cell-cell adhesion; positive regulation of peptidyl-tyrosine phosphorylation; ureteric bud branching; cartilage development; carbohydrate metabolic process; blood coagulation; leukocyte migration; healing during inflammatory response; hyaluronan metabolic process; negative regulation of apoptosis. Disease: Blood Group, Indian System
尺寸1 :
0.1毫克
价格1 :
680美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。