抗体

CYP19A1, 号码(细胞色素P450 19A1, CYPXIX, 雌激素合成酶, P-450AROM, 芳香酶, 细胞色素P-450AROM, ARO1, CYAR, CYP19)

MBS6011765

0.05毫克

695美元

多克隆

山羊

未共轭

免疫印迹, 酶联免疫吸附测定, 免疫组化, 酶免疫法

抗体

CYP19A1, 号码(细胞色素P450 19A1, CYPXIX, 雌激素合成酶, P-450AROM, 芳香酶, 细胞色素P-450AROM, ARO1, CYAR, CYP19)

[CYP19A1]

[抗-CYP19A1, 号码(细胞色素P450 19A1, CYPXIX, 雌激素合成酶, P-450AROM, 芳香酶, 细胞色素P-450AROM, ARO1, CYAR, CYP19)]

[cytochrome P450 19A1; Cytochrome P450 19A1; cytochrome P450 19A1; aromatase; estrogen synthase; estrogen synthetase; cytochrome P-450AROM; microsomal monooxygenase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily XIX (aromatization of androgens); cytochrome P450, family 19, subfamily A, polypeptide 1; Aromatase; CYPXIX; Cytochrome P-450AROM; Estrogen synthase]

[CYP19A1;CYP19A1;ARO;ARO1;CPV1;CYAR;CYP19;CYPXIX;P-450AROM;ARO1;CYAR;CYP19]

CP19A_HUMAN

多克隆

IgG

山羊

人类

识别人类CYP19A1

经免疫亲和层析纯化

Supplied as a liquid in TBS, pH 7.3, 0.5% BSA, 0.02% sodium azide.

0.5毫克/毫升

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

酶联免疫吸附测定(EL/EIA), 免疫印迹(免疫印迹), 免疫组化(免疫组化)

Suitable for use in Western Blot, ELISA and Immunohistochemistry. Dilution: ELISA: 1:128,000. Western Blot: 0.1-0.3ug/ml. Immunohistochemistry (Formalin fixed paraffin embedded): 4ug/ml - Requires HIER citrate buffer, pH 6.0. Optimal dilutions to be determined by the researcher.

免疫印迹(免疫印迹)

免疫组化(免疫组化)

Immunogen: Synthetic peptide corresponding to C-HDLSLHPDETKN of human CYP19A1. Grade: Affinity Purified

Antibodies; Abs to Enzymes, Cytochrome

CYP19A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation.

13904860

NP_112503.1

NM_031226.2

P11511

Biological Oxidations Pathway (105698); C19/C18-Steroid Hormone Biosynthesis, Pregnenolone = Androstenedione = Estrone Pathway (413383); C19/C18-Steroid Hormone Biosynthesis, Pregnenolone = Androstenedione = Estrone Pathway (468268); Cytochrome P450 - Arranged By Substrate Type Pathway (105700); Endogenous Sterols Pathway (105701); Estrogen Biosynthesis Pathway (106155); FSH Signaling Pathway (672455); Integrated Breast Cancer Pathway (219801); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976)

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants. [provided by RefSeq, Jul 2008]

CYP19A1: Catalyzes the formation of aromatic C18 estrogens from C19 androgens. Belongs to the cytochrome P450 family. Protein type: Oxidoreductase; EC 1.14.14.14; Lipid Metabolism - androgen and estrogen. Chromosomal Location of Human Ortholog: 15q21.1. Cellular Component: endoplasmic reticulum membrane; membrane; endoplasmic reticulum. Molecular Function: electron carrier activity; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; heme binding; oxygen binding. Biological Process: steroid metabolic process; xenobiotic metabolic process; androgen metabolic process; steroid biosynthetic process; estrogen biosynthetic process; sterol metabolic process. Disease: Aromatase Deficiency; Aromatase Excess Syndrome

0.05毫克

695美元