抗体

Ras, pan, N,H,K

MBS605436

0.1毫升

465美元

单克隆

兔

未共轭

7H56

人类, 小鼠, 大鼠, 果蝇

免疫印迹, 酶联免疫吸附测定, 酶免疫法

抗体

Ras, pan, N,H,K

Ras, pan, N,H,K

Anti -Ras, pan, N,H,K

Ras oncogene at 85D; CG9375 gene product from transcript CG9375-RA; CG9375-PA; Ras GTPase; Ras oncogene at 85B; Ras oncogene at 85D; Ras1; Ras85D-PA; enhancer of faf; Ras oncogene at 85D

Ras85D; C-ras1; CG9375; D-Ras; D-ras-1; D-ras1; D-Ras1; Dm Ras1; DmelCG9375; Dmras85D; dRas; Dras; DRas; dras1; dRas1; dRAS1; Dras1; DRAS1; dRas85D; Dras85D; DRas85D/Ras; E(faf); E(sev)3C; EK3-4; fs(3)05703; l(3)06677; l(3)s1747; p21[Ras1]; ras; Ras; RAS; ras 1;

单克隆

IgG

7H56

兔

Drosophila, Human, Monkey, Mouse, Rat, Yeast

Recognizes endogenous levels of human total K-Ras, H-Ras and N-Ras proteins at ~21kD. Species Crossreactivity mouse, monkey, rat, Drosophila, S. cerevisiae.

Supernatant. Supernatant

Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, <0.02% sodium azide, 50% glycerol.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

酶联免疫吸附测定(EL/EIA), 免疫印迹(免疫印迹)

Suitable for use in ELISA and Western Blot. Dilution: Western Blot: 1:1000

Immunogen: Synthetic peptide corresponding to residues near the amino terminus of human K-Ras (KLH).

Antibodies; Abs to Cancer Markers

The 21kD guanine-nucleotide binding proteins (K-Ras, H-Ras and N-Ras) cycle between active (GTP-bound) and inactive (GDP-bound) forms. Receptor tyrosine kinases and G-protein-coupled receptors activate Ras, which then stimulates the Raf-MEK-MAPK pathway. GTPase-activating proteins (GAP) normally facilitate the inactivation of Ras. However, in 30% of human tumors, point mutations in Ras prevent the GAP-mediated inhibition of this pathway. The most common oncogenic Ras mutation found in tumors is Gly12 to Asp (G12D), which prevents Ras inactivation, possibly by increasing the overall rigidity of the protein.

17136430

NP_476699.1

NM_057351.5

ARMS-mediated Activation Pathway (824068); Axon Guidance Pathway (824307); Cytokine Signaling In Immune System Pathway (824551); DAP12 Interactions Pathway (824545); DAP12 Signaling Pathway (824546); Developmental Biology Pathway (824306); Disease Pathway (823917); Dorso-ventral Axis Formation Pathway (3095); Dorso-ventral Axis Formation Pathway (472); Downstream Signal Transduction Pathway (824077)

0.1毫升

465美元