抗体

GluR2, 4(谷氨酸受体)

MBS606294

0.1毫克

690美元

单克隆

小鼠

未共轭

[2Q58]

人类, 大鼠

抗体

GluR2, 4(谷氨酸受体)

[GluR2, 4]

[抗-GluR2, 4(谷氨酸受体)]

[glutamate receptor 2 isoform 1; Glutamate receptor 2; glutamate receptor 2; gluR-2; gluR-B; OTTHUMP00000165322; OTTHUMP00000165323; OTTHUMP00000165324; OTTHUMP00000220942; OTTHUMP00000220943; AMPA-selective glutamate receptor 2; glutamate receptor, ionotropic, AMPA 2; AMPA-selective glutamate receptor 2; GluR-B; GluR-K2; Glutamate receptor ionotropic, AMPA 2]

[GRIA2; GRIA2; GLUR2; GLURB; GluA2; HBGR2; GluR-K2; GLUR2]

GRIA2_HUMAN

单克隆

IgG2a

[2Q58]

小鼠

Human, Monkey, Rat

Recognizes human Glutamate Receptor 2 (GluR2) by RIA and Western Blot. Recognizes both GluR2 and GluR4 in Immunohistochemistry and Immunoprecipitation. Species crossreactivity: monkey and rat.

纯化

Supplied as a liquid in PBS. Preservative free.

7.8毫克/毫升

May be stored at 4° for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

酶联免疫吸附测定(EL/EIA), 免疫印迹(免疫印迹), 免疫组化(免疫组化), 免疫细胞化学(免疫细胞化学), 放射免疫分析法(RIA), 免疫沉淀(免疫沉淀)。 其他未被检测的应用

Immunohistochemistry: 1:500-1:1000 on 4% paraformaldehyde fixed tissue. Optimal dilutions to be determined by the researcher.

试验数据

Immunogen: Recombinant fusion protein TrpE-GluR2

Antibodies; Abs to Receptors

Glutamate receptors are the major excitatory neurotransmitter receptors in the central nervous system (CNS). They play critical roles in the mechanisms of synaptic plasticity and in the development of the nervous system. In addition, these receptors may be involved in the neuronal cell death that occurs in several neuropathological conditions.

74275354

NP_000817.2

NM_000826.3

P42262

Activation Of AMPA Receptors Pathway (106539); Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway (161033); Amyotrophic Lateral Sclerosis (ALS) Pathway (83099); Amyotrophic Lateral Sclerosis (ALS) Pathway (511); Glutamate Binding, Activation Of AMPA Receptors And Synaptic Plasticity Pathway (106536); Glutamatergic Synapse Pathway (213818); Glutamatergic Synapse Pathway (213811); Hypothetical Network For Drug Addiction Pathway (198776); Long-term Depression Pathway (83086); Long-term Depression Pathway (497)

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG- Q- R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq]

GluR2: an integral membrane protein belonging to the glutamate-gated ion channel family. L-glutamate (Glu) acts as an excitatory neurotransmitter at many synapses in the central nervous system. Glutamate receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA(quisqualate) glutamate kainate. Each of the four GluR proteins (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. Protein type: Channel, ligand-gated; Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 4q32.1. Cellular Component: postsynaptic membrane; synaptic vesicle; endoplasmic reticulum membrane; integral to plasma membrane; dendrite; plasma membrane; cell junction. Molecular Function: protein binding; extracellular-glutamate-gated ion channel activity; ionotropic glutamate receptor activity; alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity. Biological Process: synaptic transmission; synaptic transmission, glutamatergic; ionotropic glutamate receptor signaling pathway; signal transduction

0.1毫克

690美元