产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
IKK alpha, beta, phosphorylated (Ser180/181) (IkappaB Kinase alpha, beta, IKKa,b)
目录 :
MBS627082
规格 :
0.05毫克
价格 :
390美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 酶免疫法
更多信息或购买 :
产品信息
目录号 :
MBS627082
产品类型 :
抗体
产品全称 :
IKK alpha, beta, phosphorylated (Ser180/181) (IkappaB Kinase alpha, beta, IKKa,b)
产品简称 :
IKK甲, 乙
产品名称同义词 :
Anti -IKK alpha, beta, phosphorylated (Ser180/181) (IkappaB Kinase alpha, beta, IKKa,b)
其他名称 :
inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1; Inhibitor of nuclear factor kappa-B kinase subunit beta; inhibitor of nuclear factor kappa-B kinase subunit beta; IKK-B; I-kappa-B kinase 2; I-kappa-B-kinase beta; nuclear factor NF-kappa-B inhibitor kinase beta; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta
其他基因名称 :
IKBKB; IKBKB; IKK2; IKKB; NFKBIKB; IKK-beta; IKKB; I-kappa-B-kinase beta; IKK-B; IKK-beta; IkBKB; IKK2; NFKBIKB
UniProt数据库进入名 :
IKKB_HUMAN
克隆性 :
多克隆
抗体亚型 :
IgG
宿主 :
反应物种 :
人类, 小鼠, 大鼠
特异性 :
Recognizes human IKK alpha, beta only when phosphorylated at serine 180/181. Species Crossreactivity: mouse, rat.
纯度 :
亲和纯化。 经免疫亲和层析纯化
形式 :
Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
储存稳定性 :
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
检测过的应用 :
酶联免疫吸附测定(EL/EIA), 免疫印迹(免疫印迹), 免疫组化(免疫组化)
应用笔记 :
Suitable for use in ELISA, Western Blot and Immunohistochemistry. Dilution: ELISA: 1:4000. Western Blot: 1:500-1:1000. Immunohistochemistry: 1:50-1:100
其它信息1 :
Immunogen: Synthetic phosphopeptide corresponding to human IKKa/b around the phosphorylation site of serine 180/181 (C-T-pS-F-V).
产品种类 :
Antibodies; Abs to Protein Kinases
产品描述 :
The NF-kappaB/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory IkappaB proteins. Most agents that activate NF-kappaB do so through a common pathway based on phosphorylation-induced, proteasome-mediated degradation of IkappaB. The key regulatory step in this pathway involves activation of a high molecular weight IkappaB kinase (IKK) complex, whose catalysis is generally carried out by three tightly associated IKK subunits. IKKalpha and IKKbeta serve as the catalytic subunit of the kinase. IKKgamma serves as its regulatory subunit. Activation of IKK depends on phosphorylation, and the serines 177 and 181 in the activation loop of IKKbeta (176 and 180 in IKKalpha) are the specific sites whose phosphorylation causes a conformational change that results in kinase activation.
NCBI GI登录号 :
41352712
NCBI登录号 :
NP_001547.1
NCBI基因登录号 :
NM_001556.2
UniProt数据库登录号 :
O14920
NCBI分子量 :
86,564 Da
NCBI信号通路 :
AGE/RAGE Pathway (698754); Activated TLR4 Signalling Pathway (106400); Activation Of NF-kappaB In B Cells Pathway (576251); Acute Myeloid Leukemia Pathway (83117); Acute Myeloid Leukemia Pathway (529); Adaptive Immune System Pathway (366160); Adipocytokine Signaling Pathway (83093); Adipocytokine Signaling Pathway (505); Apoptosis Pathway (198797); Apoptosis Pathway (83060)
NCBI总结 :
The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011]
UniProt数据库总结 :
IKKB: a kinase of the IKK family. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Preferentially found as a heterodimer with IKK-alpha but also as an homodimer. Protein type: EC 2.7.11.10; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Other group; IKK family. Chromosomal Location of Human Ortholog: 8p11.2. Cellular Component: internal side of plasma membrane; cytoplasm; IkappaB kinase complex; cytosol; nucleus; lipid raft. Molecular Function: protein serine/threonine kinase activity; protein binding; protein homodimerization activity; IkappaB kinase activity; protein heterodimerization activity; protein kinase binding; ATP binding; protein kinase activity. Biological Process: I-kappaB kinase/NF-kappaB cascade; nerve growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; toll-like receptor 3 signaling pathway; protein amino acid phosphorylation; T cell receptor signaling pathway; activation of NF-kappaB transcription factor; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; B cell homeostasis; positive regulation of interferon type I production; inflammatory response; toll-like receptor 4 signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; response to virus; MyD88-independent toll-like receptor signaling pathway; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; serine phosphorylation of STAT protein; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; I-kappaB phosphorylation; negative regulation of apoptosis. Disease: Immunodeficiency 15
尺寸1 :
0.05毫克
价格1 :
390美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。