产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
肌动蛋白, 甲, 平滑肌(PE)
目录 :
MBS633258
规格 :
100试验
价格 :
710美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
PE
克隆名称 :
[9H15]
反应物种 :
人类, 小鼠, 大鼠, , ,
应用 :
流式细胞仪, 流式细胞仪
更多信息或购买 :
图像
图像 1 :
MyBioSource MBS633258 图像 1
Intracellular staining of the mouse fibroblast cell line L929 with MBS633258 (filled histogram) or with isotype control (open histogram).
产品信息
目录号 :
MBS633258
产品类型 :
抗体
产品全称 :
肌动蛋白, 甲, 平滑肌(PE)
产品简称 :
[肌动蛋白, 甲, 平滑肌]
产品名称同义词 :
[Anti -Actin, alpha, Smooth Muscle (PE)]
其他名称 :
[actin, alpha 2, smooth muscle, aorta, isoform CRA_a; Actin, aortic smooth muscle; actin, aortic smooth muscle; alpha-cardiac actin; cell growth-inhibiting gene 46 protein; actin, alpha 2, smooth muscle, aorta; Alpha-actin-2; Cell growth-inhibiting gene 46 protein]
其他基因名称 :
[大动脉平滑肌肌动蛋白alpha2;大动脉平滑肌肌动蛋白alpha2;AAT6;ACTSA;MYMY5;ACTSA;ACTVS]
UniProt数据库进入名 :
ACTA_HUMAN
克隆性 :
单克隆
抗体亚型 :
IgG2a
克隆 :
[9H15]
宿主 :
小鼠
反应物种 :
Bovine, Canine, Chicken, Frog, Goat, Guinea Pig, Human, Mouse, Rabbit, Rat, Sheep
特异性 :
Recognizes human alpha-Smooth Muscle Actin. Species Crossreactivity: bovine, chicken, frog, goat, guinea pig, mouse, rabbit, rat, canine, sheep and snake.
纯度 :
Affinity Purified. Purified by Protein G affinity chromatography
形式 :
Supplied as a liquid in saline, 0.5% BSA, 0.1% sodium azide. Labeled with R-Phycoerythrin (PE).
储存稳定性 :
4 degree C Do not freeze
检测过的应用 :
流式细胞仪(FC/流式细胞仪)
应用笔记 :
Suitable for use in Flow Cytometry. Dilution: Flow Cytometry: Neat. 10ul labels up to 1x10e6 cells.
image1头 :
试验数据
其它信息1 :
Immunogen: Synthetic decapeptide corresponding to the N-terminal residues of human alpha-Smooth Muscle Actin.
其他信息2 :
Hybridoma: Fusion of a mouse myeloma with B cells obtained from a rat immunized with a synthetic decapeptide from the N-terminal of Alpha-Smooth Muscle Actin. Storage and Stability:. Maybe stored at 4 degree C before opening. DO NOT FREEZE! Stable for 12 months at 4 degree C. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light.
产品种类 :
Antibodies; Abs to Actin Related Proteins
产品描述 :
Actins are highly conserved proteins expressed in all eucaryotic cells. Actin filaments form part of the cytoskeleton and play essential roles in regulating cell shape and movement. Six distinct actin isotypes have been identified in mammalian cells. Each is encoded by a separated gene and is expressed in a developmentally regulated and tissue-specific manner, alpha and beta cytoplasmic actins are expressed in a wide variety of cells; whereas, expression of alpha skeletal, alpha cardiac, alpha vascular, and gamma enteric actins are more restricted to specialized muscle cell type. Smooth muscle alpha actin is of further interest because it is one of a few genes whose expression is relatively restricted to vascular smooth muscle cells. Further more, expression of smooth muscle alpha actin is regulated by hormones, cell proliferation, and altered by pathological conditions including oncogenic transformation and atherosclerosis.
NCBI GI登录号 :
119570540
NCBI登录号 :
EAW50155.1
UniProt数据库登录号 :
P62736
NCBI分子量 :
42,009 Da
NCBI信号通路 :
Muscle Contraction Pathway (106261); Myometrial Relaxation And Contraction Pathways (198759); Smooth Muscle Contraction Pathway (161025); Striated Muscle Contraction Pathway (198903); Vascular Smooth Muscle Contraction Pathway (96530); Vascular Smooth Muscle Contraction Pathway (96866)
NCBI总结 :
The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]
UniProt数据库总结 :
ACTA2: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Up-regulated in response to enterovirus 71 (EV71) infection. Belongs to the actin family. Protein type: Contractile; Cytoskeletal; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 10q23.3. Cellular Component: extracellular space; smooth muscle contractile fiber; protein complex; cytoplasm; cytosol; actin cytoskeleton. Molecular Function: protein kinase binding; ATP binding. Biological Process: muscle contraction; response to virus; regulation of blood pressure; vascular smooth muscle contraction. Disease: Multisystemic Smooth Muscle Dysfunction Syndrome; Moyamoya Disease 5; Aortic Aneurysm, Familial Thoracic 6
尺寸1 :
100试验
价格1 :
710美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。