产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
单克隆抗体mTLR3(ABM24E5)
目录 :
MBS668027
规格 :
0.1毫克
价格 :
290美元
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
未共轭
克隆名称 :
[ABM24E5]
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化, 流式细胞仪
更多信息或购买 :
图像
图像 1 :
MyBioSource MBS668027 图像 1
Intracellular flow analysis of mTLR3 in m Splenocytes using 0.5 tJg/1 0"6 cells of mTLR3 antibody (Clone: ABM24E5). Green represents isotype control; red represents anti-mTLR3 antibody. Goat anti-Rat FITe conjugate was used as secondary antibody .
图像 2 :
MyBioSource MBS668027 图像 2
Immunohistochemical analysis of mTLR3 in human Liver tissue using mTLR3 antibody (Clone:ABM24ES) at 10 ug/ml.
产品信息
目录号 :
MBS668027
产品类型 :
抗体
产品全称 :
单克隆抗体mTLR3(ABM24E5)
产品简称 :
[mTLR3]
产品名称同义词 :
[Toll样受体3]
其他名称 :
[Toll样受体3;Toll样受体3;Toll样受体3;Toll样受体3;CD_antigen:CD283]
产品基因名称 :
[mTLR3]
其他基因名称 :
[Toll样受体3;Toll样受体3;AI957183]
UniProt数据库进入名 :
TLR3_MOUSE
克隆性 :
单克隆
抗体亚型 :
Rat IgG2b, Kappa
克隆 :
[ABM24E5]
宿主 :
大鼠
反应物种 :
小鼠, 人类
序列长度 :
905
纯度 :
蛋白质G色谱
形式 :
纯化(液体)
储存稳定性 :
Store the antibody at 4 degree C, stable for 6 months. For long-term storage, store at -20 degree C. Avoid repeated freeze and thaw cycles.
检测过的应用 :
免疫印迹(免疫印迹), 流式细胞仪, 免疫组化(免疫组化)
应用笔记 :
Western blot analysis: 2-4 ug/ml; FACS analysis: 0.5 ug/10^6 cells; Immunohistochemical analysis: 10ug/ml
image1头 :
免疫印迹(免疫印迹)
image2头 :
流式细胞仪
image3头 :
Immunohistochemical
其它信息1 :
Antigen: mTLR3. Content: 100 ug in 200ul PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
其他信息2 :
Immunogen: A partial length recombinant mTLR3 protein (Amino acid sequence 180-385) was used as the immunogen for this antibody.
产品种类 :
TLR
产品描述 :
Mouse Toll-like receptor 3 (mTLR3) belongs to a family of evolutionary conserved innate immune recognition molecules and recognizes double-stranded RNA, a molecular pattern associated with viral infections. It has seven exons. mTlr3 show high homology to hTLR3 in their predicted cDNA and protein sequences. The intracellular region of mTlr3 has remarkable homology with the same region of others mTlrs. mTlr3 mRNA is ubiquitously expressed in tissues, being expressed highest in spleen, kidney and lung. Its activation by the synthetic ligand polyinosine:polycytidylic acid (poly I:C) or by mRNA rapidly causes growth cone collapse and irreversibly inhibits neurite extension independent of NF-kappaB. The high levels of mTlr3 expression in Mz B cells perhaps contribute to their ability to clear antigen from the blood.
NCBI GI登录号 :
31543872
NCBI登录号 :
NP_569054.2
NCBI基因登录号 :
NM_126166.4
UniProt数据库登录号 :
Q99MB1
NCBI信号通路 :
Activated TLR4 Signalling Pathway (1168911); Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway (1168897); Apoptosis Pathway (1167740); Caspase Activation Via Extrinsic Apoptotic Signalig Pathway (1167741); Cytosolic Sensors Of Pathogen-associated DNA Pathway (1168940); Hepatitis B Pathway (694729); Hepatitis C Pathway (173974); Hepatitis C Pathway (173907); Herpes Simplex Infection Pathway (377874); Herpes Simplex Infection Pathway (377865)
UniProt数据库总结 :
TLR3: a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. Most abundantly expressed in placenta and pancreas. Restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection. Acts via MyD88 and TRAF6, leading to the activation of NF-kappaB and the production of type I interferon. Protein type: Receptor, cytokine; Membrane protein, integral. Cellular Component: cell surface; membrane; endoplasmic reticulum; lysosomal membrane; cytoplasm; integral to membrane; intracellular; endosome. Molecular Function: identical protein binding; protein binding; transmembrane receptor activity; RNA binding; double-stranded RNA binding; receptor activity. Biological Process: positive regulation of interleukin-12 production; positive regulation of JNK cascade; microglial cell activation; positive regulation of NF-kappaB import into nucleus; positive regulation of interferon-alpha biosynthetic process; defense response; toll-like receptor 3 signaling pathway; signal transduction; activation of NF-kappaB transcription factor; positive regulation of interleukin-8 production; response to exogenous dsRNA; positive regulation of interferon-beta production; positive regulation of interferon type I production; inflammatory response; defense response to virus; positive regulation of cytokine production; positive regulation of I-kappaB kinase/NF-kappaB cascade; immune system process; response to virus; MyD88-independent toll-like receptor signaling pathway; response to dsRNA; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; positive regulation of chemokine production; positive regulation of toll-like receptor signaling pathway; positive regulation of chemokine biosynthetic process; positive regulation of interferon-beta biosynthetic process; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; I-kappaB phosphorylation; microglial cell activation during immune response; positive regulation of interferon-gamma biosynthetic process; positive regulation of inflammatory response
尺寸1 :
0.1毫克
价格1 :
290美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。