抗体

大鼠抗人类IL-13

MBS670052

0.5毫克

320美元

单克隆

大鼠

nonconjugated

JES10-35G12

抗体

大鼠抗人类IL-13

IL-13

Rat Anti-Human IL-13 - Purified, Unlabeled Antibody; Rat Anti-Human IL-13

interleukin-13; Interleukin-13; interleukin-13; allergic rhinitis; OTTHUMP00000066048; Bronchial hyperresponsiveness-1 (bronchial asthma); interleukin 13

白细胞介素-13;白细胞介素-13;ALRH;BHR1;P600;IL-13;MGC116786;MGC116788;MGC116789;NC30

IL13_HUMAN

单克隆

Rat IgG2a kappa

JES10-35G12

大鼠

人类

132

Human Interleukin-13 (IL-13)1,2 (This is a neutralizing antibody.)

纯化(UNLB)抗体

The purified (UNLB) antibody is supplied as 0.5 mg purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added. Store at 2- 8 degree C. Reagents are stable for the period shown on the label if stored as directed.

酶联免疫吸附测定

Research Application(s): ELISA Capture: JES10-35G12 monoclonal antibody is useful as a capture antibody in a sandwich ELISA for quantifying human IL-13 protein levels.1,2 Purified JES10-35G12 antibody should be paired with biotinylated JES2E10 antibody as the detection antibody, with purified recombinant human IL-13 as the standard. Since applications vary, each investigator should determine the optimal concentration appropriate for individual applications.

Immunogen: COS-expressed recombinant human IL-13

Characterization: To ensure acceptable performance, each batch of product is tested in a sandwich ELISA to conform to characteristics of a standard reference reagent.

1. McKenzie, A., and G. Zurawski. 1994. Measurement of IL-13. In Current Protocols in Immunology (J. Coligamn, A. Kruisbeek, D. Margulies, E. Shevach, W. Strober, eds.). John Wiley and Sons, New York. Unit 6.18. 2. Abrams, J. 1995. Immunoenzymetric assay of mouse and human cytokines using NIP-labeled anti-cytokine antibodies. In Current Protocols in Immunology (J. Coligamn, A. Kruisbeek, D. Margulies, E. Shevach, W. Strober, eds.). John Wiley and Sons, New York. Unit 6.20.

1045452

P35225

15,816 Da

Asthma Pathway 83120!!Asthma Pathway 532!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Cytokines And Inflammatory Response Pathway 198794!!Fc Epsilon RI Signaling Pathway 83082!!Fc Epsilon RI Signaling Pathway 493!!Glucocorticoid Receptor Regulatory Network Pathway 138014!!IL12 Signaling Mediated By STAT4 Pathway 137936!!Jak-STAT Signaling Pathway 83077

This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq]

Function: Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Subunit structure: Interacts with IL13RA2. Subcellular location: Secreted. Involvement in disease: Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH) [. MIM:607154]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure. Sequence similarities: Belongs to the IL-4/IL-13 family. Caution: It is uncertain whether Met-1 or Met-15 is the initiator. Sequence caution: The sequence AAA36107.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAA83738.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAB01681.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAC03535.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAK53823.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence CAA48824.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

0.5毫克

320美元