产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
大鼠抗小鼠GM-CSF/AF
目录 :
MBS670098
规格 :
0.5毫克
价格 :
315美元
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
未共轭
克隆名称 :
MP1-22E9
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 酶联免疫吸附测定
更多信息或购买 :
产品信息
目录号 :
MBS670098
产品类型 :
抗体
产品全称 :
大鼠抗小鼠GM-CSF/AF
产品简称 :
GM-CSF
产品名称同义词 :
大鼠抗小鼠GM-CSF-低内毒素/无叠氮物;大鼠抗小鼠GM-CSF
其他名称 :
GM-CSF; Granulocyte-macrophage colony-stimulating factor; granulocyte-macrophage colony-stimulating factor; CSF; molgramostin; sargramostim; OTTHUMP00000065962; granulocyte-macrophage colony stimulating factor; colony stimulating factor 2 (granulocyte-macrophage); Colony-stimulating factor; CSF; Molgramostin; Sargramostim
其他基因名称 :
CSF2;CSF2;GMCSF;MGC131935;MGC138897;GMCSF
UniProt数据库进入名 :
CSF2_HUMAN
克隆性 :
单克隆
抗体亚型 :
Rat IgG2a kappa
克隆 :
MP1-22E9
宿主 :
大鼠
反应物种 :
小鼠
序列长度 :
144
特异性 :
Mouse Granulocyte/Macrophage Colony Stimulating Factor (GM-CSF)1-3 (This is a neutralizing antibody.)
形式 :
Low Endotoxin, Azide - Free (LE/AF)
储存稳定性 :
The purified (UNLB) antibody is supplied as 0.5 mg purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added. Store at 2- 8 degree C. The low endotoxin, azide-free (LE/AF) antibody is supplied as 0.5 mg purified immunoglobulin in 1.0 mL of PBS. Aliquot and store at or below -20 degree C. Aliquot and freeze the low endotoxin, azide-free product at -20 degree C immediately upon receipt. Each reagent is stable for the period shown on the bottle label if stored as directed.
检测过的应用 :
酶联免疫吸附测定;免疫印迹
应用笔记 :
Research Application(s): ELISA Capture: MP1-22E9 monoclonal antibody is useful as a capture antibody in a sandwich ELISA for quantifying mouse GM-CSF protein levels. Purified MP1-22E9 antibody should be paired with biotinylated MP1-31G6 antibody as the detection antibody, with purified recombinant mouse GM-CSF as the standard. Western Blotting: The purified MP1-22E9 antibody is also useful for Western blotting applications. For Western blotting, a concentration of 1-5 ug/mL (in conjunction with AP-labeled Goat Anti-Rat-Ig) has been found to enable detection of <= 100 ng/lane of recombinant mouse GM-CSF under reducing conditions. Neutralization: The LE/AF form of MP1-22E9 can be used for neutralizing mouse GM-CSF bioactivity. A suitable LE/AF Rat IgG2a should be used as an isotype control. Since applications vary, each investigator should determine the optimal concentration appropriate for individual applications.
其它信息1 :
Immunogen: Yeast-expressed recombinant mouse GM-CSF
其他信息2 :
Characterization: To ensure acceptable performance, each batch of product is tested in a sandwich ELISA to conform to characteristics of a standard reference reagent.
产品引用 :
1. Sander, B., I. Hoiden, U. Andersson, E. Moller, and J. Abrams. 1993. J. Immunol. Meth. 166:201. 2. Suda, T., A. O'Garra, I. MacNeil, M. Fischer, M. Bond, and A. Zlotnik. 1990. Cell. Immunol. 129:228. 3. Nozaki, S., J. Abrams, M. Pearce, and D. Sauder. 1991. J. Invest. Dermatol. 97:10.
NCBI GI登录号 :
183364
UniProt数据库登录号 :
P04141
NCBI分子量 :
16,295 Da
NCBI信号通路 :
Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway (137993); Calcium Signaling In The CD4+ TCR Pathway (137941); Cytokine Signaling In Immune System Pathway (366171); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Cytokines And Inflammatory Response Pathway (198794); Fc Epsilon RI Signaling Pathway (83082); Fc Epsilon RI Signaling Pathway (493)
NCBI总结 :
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq]
UniProt数据库总结 :
Function: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. Subunit structure: Monomer. Subcellular location: Secreted. Polymorphism: Variant Ile-117 may be a risk factor for atopic asthma. Pharmaceutical use: Available under the names Leukine (Immunex) and Leucomax (Novartis). Used in myeloid reconstitution following bone marrow transplant, bone marrow transplant engraftment failure or delay, mobilization and following transplantation of autologous peripheral blood progenitor cells, and following induction chemotherapy in older adults with acute myelogenous leukemia. Sequence similarities: Belongs to the GM-CSF family.
尺寸1 :
0.5毫克
价格1 :
315美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。